Anti-NMDA receptor encephalitis presenting as isolated aphasia in an adult

被引：10

作者：

Constantinides, Vasilios C. ^{[1
]}

Kasselimis, Dimitrios S. ^{[1
,2
]}

Paraskevas, George P. ^{[1
]}

Zacharopoulou, Maria ^{[1
]}

Andreadou, Elisabeth ^{[1
]}

Evangelopoulos, Maria-Eleftheria ^{[1
]}

Kapaki, Elisabeth ^{[1
]}

Kilidireas, Costas ^{[1
]}

Stamboulis, Eleftherios ^{[1
]}

Potagas, Constantin ^{[1
]}

机构：

[1] Univ Athens, Eginit Hosp, Dept Neurol 1, Athens, Greece

[2] Univ Crete, Sch Med, Dept Psychiat, Iraklion, Greece

来源：

NEUROCASE | 2018年 / 24卷 / 04期

关键词：

Anti-NMDA-r encephalitis; aphasia; immunotherapy; language; cognitive decline; NONCONVULSIVE STATUS EPILEPTICUS; ANTIBODIES ENCEPHALITIS; AUTOIMMUNE ENCEPHALITIS; VOCABULARY MEASURES; OVARIAN TERATOMA; ACUTE-PSYCHOSIS; DIAGNOSIS; GREEK; MIMICKING; CHILDREN;

D O I：

10.1080/13554794.2018.1524915

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Anti-NMDA receptor (NMDA-r) encephalitis is a relatively rare cause of autoimmune encephalitis with divergent clinical presentations. We report a case of an adult patient with anti-NMDA-r encephalitis presenting with isolated, abrupt-onset aphasia. Her condition remained unaltered over a period of 6months. The patients' electroencephalogram findings were typical for NMDA-r encephalitis; however, her magnetic resonance imaging and cerebrospinal fluid analysis were normal. She responded well to immunotherapy, and aphasia eventually resolved. The natural course of the present case contradicts the rapidly progressive nature of typical NMDA-r encephalitis. Furthermore, it broadens the clinical spectrum of anti-NMDA-r encephalitis, to incorporate isolated, nonprogressive aphasia.

引用

页码：188 / 194

页数：7

共 50 条

[31] Abnormal multifocal cerebral blood flow on Tc-99m HMPAO SPECT in a patient with anti-NMDA-receptor encephalitis [J].

Llorens, Veronica ;

Gabilondo, Inigo ;

Carlos Gomez-Esteban, Juan ;

Agundez, Marta ;

Mendibe, Mar ;

Carlos Bergara, Juan ;

Ciordia, Roberto ;

Saiz, Albert ;

Zarranz, Juan J. .

JOURNAL OF NEUROLOGY, 2010, 257 (09) :1568-1569

[32] Anti-NMDA receptor encephalitis presenting with total insomnia - A case report [J].

Marques, Ines Bras ;

Teotonio, Rute ;

Cunha, Catarina ;

Bento, Conceicao ;

Sales, Francisco .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 2014, 336 (1-2) :276-280

[33]

Nath Uma, 2011, BMJ Case Rep, V2011, DOI 10.1136/bcr.12.2010.3579

[34] Reversible limbic encephalitis caused by ovarian teratoma [J].

Nokura, K ;

Yamamoto, H ;

Okawara, Y ;

Koga, H ;

Osawa, H ;

Sakai, K .

ACTA NEUROLOGICA SCANDINAVICA, 1997, 95 (06) :367-373

[35] The Role of NMDA Receptors in Human Eating Behavior: Evidence From a Case of Anti-NMDA Receptor Encephalitis [J].

Perogamvros, Lampros ;

Schnider, Armin ;

Leemann, Beatrice .

COGNITIVE AND BEHAVIORAL NEUROLOGY, 2012, 25 (02) :93-97

[36] Acute psychosis in anti-NMDA-receptor encephalitis [J].

Sacre, Karim ;

Lidove, Olivier ;

Chanson, Noemie ;

Laganier, Jean ;

Vidailhet, Marie ;

Lejoyeux, Michel ;

Papo, Thomas .

PRESSE MEDICALE, 2011, 40 (09) :882-884

[37]

Sawamura H., 2014, OFFICIAL J N AM NEUR, V34, P1

[38] Verbal Comprehension Ability in Aphasia: Demographic and Lexical Knowledge Effects [J].

Simos, Panagiotis G. ;

Kasselimis, Dimitrios ;

Potagas, Constantin ;

Evdokimidis, Ioannis .

BEHAVIOURAL NEUROLOGY, 2014, 2014

[39]

Simos PG, 2013, J INT NEUROPSYCH SOC, V19, P355, DOI 10.1017/S1355617712001518

[40] Effects of demographic variables and health status on brief vocabulary measures in Greek [J].

Simos, Panagiotis G. ;

Kasselimis, Dimitrios ;

Mouzaki, Angeliki .

APHASIOLOGY, 2011, 25 (04) :492-504

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