Vagus nerve stimulation for epilepsy: Randomized comparison of three stimulation paradigms

被引：75

作者：

DeGiorgio, C

Heck, C

Bunch, S

Britton, J

Green, P

Lancman, M

Murphy, J

Olejniczak, P

Shih, J

Arrambide, S

Soss, J

机构：

[1] Univ Calif Los Angeles, Geffen Sch Med, Los Angeles, CA USA

[2] USC, Keck Sch Med, Los Angeles, CA USA

[3] Mayo Clin, Rochester, MN USA

[4] Borgess Med Ctr, Res Grp, Kalamazoo, MI USA

[5] NE Reg Epilepsy Grp, White Plains, NY USA

[6] Childrens Mercy Hosp, Kansas City, MO 64108 USA

[7] LSU HSC Epilepsy Ctr Excellence, New Orleans, LA USA

[8] Univ New Mexico, Sch Med, Albuquerque, NM 87131 USA

[9] SYNERGOS Biomed Consulting, The Woodlands, TX USA

来源：

NEUROLOGY | 2005年 / 65卷 / 02期

关键词：

D O I：

10.1212/01.wnl.0000168899.11598.00

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Vagus nerve stimulation (VNS) is an effective adjunctive treatment for intractable epilepsy. However, the optimal range of device duty-cycles [on/( on + off times)] is poorly understood. The authors performed a multicenter, randomized trial of three unique modes of VNS, which varied primarily by duty-cycle. The results indicate that the three duty-cycles were equally effective. The data support the use of standard duty-cycles as initial therapy.

引用

页码：317 / 319

页数：3

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