Suppression of aging in mice by the hormone Klotho

被引：1485
作者：
Kurosu, H
Yamamoto, M
Clark, JD
Pastor, JV
Nandi, A
Gurnani, P
McGuinness, OP
Chikuda, H
Yamaguchi, M
Kawaguchi, H
Shimomura, I
Takayama, Y
Herz, J
Kahn, CR
Rosenblatt, KP
Kuro-o, M
机构：
[1] Univ Texas, SW Med Ctr Dallas, Dept Pathol, Dallas, TX 75390 USA
[2] Univ Texas, SW Med Ctr Dallas, Dept Mol Genet, Dallas, TX 75390 USA
[3] Vanderbilt Univ, Sch Med, Dept Physiol & Mol Biophys, Nashville, TN 37232 USA
[4] Univ Tokyo, Dept Sensory & Motor Syst Med, Bunkyo Ku, Tokyo 1138655, Japan
[5] Osaka Univ, Dept Internal Med & Mol Sci, Suita, Osaka 5650871, Japan
[6] Harvard Univ, Sch Med, Joslin Diabet Ctr, Dept Med,Res Div, Boston, MA 02215 USA
来源：
SCIENCE | 2005年 / 309卷 / 5742期
基金：
美国国家科学基金会;
关键词：
D O I：
10.1126/science.1112766
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A defect in Klotho gene expression in mice accelerates the degeneration of multiple age-sensitive traits. Here, we show that overexpression of Klotho in mice extends life span. Klotho protein functions as a circulating hormone that binds to a cell-surface receptor and represses intracellular signals of insulin and insulin-like growth factor 1 (IGF1), an evolutionarily conserved mechanism for extending life span. Alleviation of aging-like phenotypes in Klotho-deficient mice was observed by perturbing insulin and IGF1 signaling, suggesting that Klotho-mediated inhibition of insulin and IGF1 signaling contributes to its anti-aging properties. Klotho protein may function as an anti-aging hormone in mammals.
引用
收藏
页码：1829 / 1833
页数：5
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