Role of the microbiota in skin immunity and atopic dermatitis

被引：76

作者：

Yamazaki, Yuriko ^{[1
]}

Nakamura, Yuumi ^{[1
]}

Nunez, Gabriel ^{[2
,3
]}

机构：

[1] Chiba Univ, Grad Sch Med, Dept Dermatol, Chiba, Japan

[2] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI USA

[3] Univ Michigan, Sch Med, Ctr Comprehens Canc, Ann Arbor, MI USA

来源：

ALLERGOLOGY INTERNATIONAL | 2017年 / 66卷 / 04期

关键词：

Atopic dermatitis; Microbiota; Quorum sensing; Staphylococcus aureus; delta-toxin; HYPER-IGE SYNDROME; CHRONIC MUCOCUTANEOUS CANDIDIASIS; PHENOL-SOLUBLE MODULINS; DS-NH MICE; STAPHYLOCOCCUS-AUREUS; CELL-DIFFERENTIATION; IMMUNOGLOBULIN-E; NC/NGA MICE; T-CELLS; BARRIER;

D O I：

10.1016/j.alit.2017.08.004

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects 15-20% of children and 2-5% of adults in industrialized countries. The pathogen Staphylococcus aureus selectively colonizes the lesional skin of AD patients while this bacterium is absent in the skin of the majority of healthy individuals. However, the role of S. aureus in the pathogenesis of AD remains poorly understood. In addition to S. aureus, recent studies show a contribution of the skin microbiota to the regulation of immune responses in the skin as well as to the development of inflammatory skin disease. This review summarizes current knowledge about the role of the microbiota in skin immune responses and the role of S. aureus virulent factors in the pathogenesis of AD. Copyright (C) 2017, Japanese Society of Allergology. Production and hosting by Elsevier B.V.

引用

页码：539 / 544

页数：6

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