This paper introduces the system of monitoring and controlling the changes of temperature and humidity in the laboratory. A hardware-software system with fuzzy control is set up by using microcomputer and fuzzy control techniques. With such a system, the temperature-humidity can keep its variations up to the requirement of the system in operation and the reliability of the operation of system is also raised effectively. The system used bussing technique, which made itself simple in structure and easy to operate. Therefore, the system can also be applied to the other temperature-humidity control process.