Capnocytophaga canimorsus Capsular Serovar and Disease Severity, Helsinki Hospital District, Finland, 2000-2017

被引：15

作者：

Hess, Estelle ^{[1
]}

Renzi, Francesco ^{[1
]}

Karhunen, Panu ^{[2
]}

Dol, Melanie ^{[1
]}

Lefevre, Adrien ^{[1
]}

Antikainen, Jenni ^{[3
,4
]}

Carlier, Elodie ^{[1
]}

Hastbacka, Johanna ^{[3
,4
]}

Cornelis, Guy R. ^{[1
]}

机构：

[1] Univ Namur, Namur, Belgium

[2] Univ Eastern Finland, Kuopio, Finland

[3] Univ Helsinki, Helsinki, Finland

[4] Helsinki Univ Hosp, Helsinki, Finland

来源：

EMERGING INFECTIOUS DISEASES | 2018年 / 24卷 / 12期

关键词：

INFECTION;

D O I：

10.3201/eid2412.172060

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We assembled a collection of 73 Capnocytophaga canimorsus isolates obtained from blood cultures taken from patients treated at Helsinki University Hospital (Helsinki, Finland) during 2000-2017. We serotyped these isolates by PCR and Western blot and attempted to correlate pathogen serovar with patient characteristics. Our analyses showed, in agreement with previous research, that 3 C. canimorsus serovars (A-C) caused most (91.8%) human infections, despite constituting only 7.6% of isolates found in dogs. The 3 fatalities that occurred in our cohort were equally represented by these serovars. We found 2 untypeable isolates, which we designated serovars J and K. We did not detect an association between serovar and disease severity, immune status, alcohol abuse, or smoking status, but dog bites occurred more frequently among patients infected with non-A-C serovars. Future research is needed to confirm serovar virulence and develop strategies to reduce risk for these infections in humans.

引用

页码：2195 / 2201

页数：7

共 14 条

[1] Capnocytophaga canimorsus: an emerging cause of sepsis, meningitis, and post-splenectomy infection after dog bites [J].