Dysregulated CD40 and CD40 ligand expression in anti-N-methyl-D-aspartate receptor encephalitis

被引：3

作者：

Ma, Xiaoyu ^{[1
]}

Chen, Chen ^{[1
]}

Fang, Ling ^{[1
,2
]}

Zhong, Xiaonan ^{[1
]}

Chang, Yanyu ^{[1
]}

Li, Rui ^{[1
]}

Wang, Yuge ^{[1
]}

Hu, Xueqiang ^{[1
]}

Qiu, Wei ^{[1
]}

Shu, Yaqing ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Dept Neurol, Affiliated Hosp 3, Guangzhou, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Dept Radiol, Affiliated Hosp 3, Guangzhou, Guangdong, Peoples R China

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2022年 / 362卷

基金：

中国国家自然科学基金;

关键词：

Serum; CD40; ligand; Pathway; Anti-N-methyl-D-aspartate receptor; encephalitis;

D O I：

10.1016/j.jneuroim.2021.577762

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Anti-N-methyl-D-aspartate receptor encephalitis (anti-NMDARE) is a B cell- and antibody-mediated autoimmune disease which may be regulated by CD40/CD40L signaling pathway. we enrolled anti-NMDARE patients and measured the serum CD40 and CD40L concentrations. The serum concentration of CD40 was decreased, while CD40L was increased in anti-NMDARE patients compared with that of healthy controls. The concentrations of CD40 and CD40L were both elevated in the acute stage of anti-NMDARE and were reduced during remission. Serum CD40L levels were positively correlated with serum CD40 levels. These results revealed that the CD40/ CD40L signaling pathway might contribute to the pathogenesis of anti-NMDARE.

引用

页数：5

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