Hyperserotonaemia and reduced brain serotonin levels in NaSl sulphate transporter null mice

被引：19
作者：
Lee, Soohyun
Kesby, James P.
Muslim, Mohammed D.
Steane, Sarah E.
Eyles, Darryl W.
Dawson, Paul A. [1 ]
Markovich, Daniel
机构：
[1] Univ Queensland, Sch Biomed Sci, St Lucia, Qld 4072, Australia
[2] Queensland Ctr Mental Hlth Res, Wacol, Australia
来源：
NEUROREPORT | 2007年 / 18卷 / 18期
关键词：
5-HT; mouse model; serotonin; Slc13al; sulphate;
D O I：
10.1097/WNR.0b013e3282f22998
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Sulphate (SO42-) is conjugated to numerous enclogenous compounds, including serotonin (5-HT). The NaSl sulphate transporter is primarily expressed in the kidney, where it maintains blood SO42- concentrations. Previously, we generated NaSl null (Nasl(-/-)) mice, which have hyposulphataemia and decreased anxiety and locomotor activity In this study, we investigated 5-HT and 5-hydroxyindole acetic acid (5-HIAA) concentrations, and 5-HT receptor mRNA levels. Nasl(-/-) mice exhibited a doubling in blood 5-HT concentration, but a 12% reduction in brain levels of 5-HT and 5-hydroxyindole acetic acid. Brain 5-HTIA and 5-HTIB receptor mRNA levels were increased by 50%, compared with wild-type mice. Our data indicate that decreased circulating SO42- concentrations modulate 5-HT neurotransmitter and receptor levels, in a manner consistent with the behavioural phenotypes of Nasl(-/-) mice.
引用
收藏
页码：1981 / 1985
页数：5
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