Photoacoustic heterodyne breath sensor for real-time measurement of human exhaled carbon monoxide

被引:15
作者
Li, Biao [1 ,2 ]
Feng, Chaofan [1 ,2 ]
Wu, Hongpeng [1 ,2 ]
Jia, Suotang [1 ,2 ]
Dong, Lei [1 ,2 ]
机构
[1] Shanxi Univ, Inst Laser Spect, State Key Lab Quantum Opt & Quantum Opt Devices, Taiyuan 030006, Peoples R China
[2] Shanxi Univ, Collaborat Innovat Ctr Extreme Opt, Taiyuan 030006, Peoples R China
基金
中国国家自然科学基金; 国家重点研发计划;
关键词
Photoacoustic spectroscopy; Photoacoustic heterodyne sensing; Breath sensor; Beat -frequency signal; Exhaled carbon monoxide;
D O I
10.1016/j.pacs.2022.100388
中图分类号
O42 [声学];
学科分类号
070206 ; 082403 ;
摘要
A breath sensor for real-time measurement of human exhaled carbon monoxide is reported. This breath sensor is based on a novel photoacoustic heterodyne gas sensing technique, which combines the conventional photoacoustic spectroscopy with the beat-frequency detection algorithm, thus offering a fast response time and a convenient optical alignment, as well as eliminating the needs for frequency calibration and wavelength locking. The principle of photoacoustic heterodyne gas sensing was explained in detail. The performance of the photoacoustic heterodyne breath sensor was evaluated in terms of minimum detection limit, response time, and linearity. The exhaled carbon monoxide levels of eight volunteers were measured and the results demonstrate the reliability and feasibility of this breath sensor.
引用
收藏
页数:6
相关论文
共 32 条
[1]   Real-time monitoring of skin ethanol gas by a high-sensitivity gas phase biosensor (bio-sniffer) for the non-invasive evaluation of volatile compounds [J].
Arakawa, Takahiro ;
Suzuki, Takuma ;
Tsujii, Masato ;
Iitani, Kenta ;
Chien, Po-Jen ;
Ye, Ming ;
Toma, Koji ;
Iwasaki, Yasuhiko ;
Mitsubayashi, Kohji .
BIOSENSORS & BIOELECTRONICS, 2019, 129 :245-253
[2]   Terahertz quartz enhanced photo-acoustic sensor [J].
Borri, S. ;
Patimisco, P. ;
Sampaolo, A. ;
Beere, H. E. ;
Ritchie, D. A. ;
Vitiello, M. S. ;
Scamarcio, G. ;
Spagnolo, V. .
APPLIED PHYSICS LETTERS, 2013, 103 (02)
[3]   Photoacoustic trace gas detection of ethylene in high-concentration methane background based on dual light sources and fiber-optic microphone [J].
Chen, Ke ;
Zhang, Bo ;
Guo, Min ;
Chen, Yewei ;
Deng, Hong ;
Yang, Beilei ;
Liu, Shuai ;
Ma, Fengxiang ;
Zhu, Feng ;
Gong, Zhenfeng ;
Yu, Qingxu .
SENSORS AND ACTUATORS B-CHEMICAL, 2020, 310
[4]   Ultra-high sensitive fiber-optic Fabry-Perot cantilever enhanced resonant photoacoustic spectroscopy [J].
Chen, Ke ;
Yu, Qingxu ;
Gong, Zhenfeng ;
Guo, Min ;
Qu, Chao .
SENSORS AND ACTUATORS B-CHEMICAL, 2018, 268 :205-209
[5]   QEPAS spectrophones: design, optimization, and performance [J].
Dong, L. ;
Kosterev, A. A. ;
Thomazy, D. ;
Tittel, F. K. .
APPLIED PHYSICS B-LASERS AND OPTICS, 2010, 100 (03) :627-635
[6]   Real-time breath gas analysis of CO and CO2 using an EC-QCL [J].
Ghorbani, Ramin ;
Schmidt, Florian M. .
APPLIED PHYSICS B-LASERS AND OPTICS, 2017, 123 (05)
[7]   Use of Expired Air Carbon Monoxide Testing in Clinical Tobacco Treatment Settings [J].
Goldstein, Adam O. ;
Gans, Stephanie P. ;
Ripley-Moffitt, Carol ;
Kotsen, Chris ;
Bars, Matthew .
CHEST, 2018, 153 (02) :554-562
[8]   Fast and Highly Sensitive Fiber-Enhanced Raman Spectroscopic Monitoring of Molecular H2 and CH4 for Point-of-Care Diagnosis of Malabsorption Disorders in Exhaled Human Breath [J].
Hanf, Stefan ;
Boegoezi, Timea ;
Keiner, Robert ;
Frosch, Torsten ;
Popp, Juergen .
ANALYTICAL CHEMISTRY, 2015, 87 (02) :982-988
[9]   Trace gas detection in a hollow-core antiresonant fiber with heterodyne phase-sensitive dispersion spectroscopy [J].
Hu, Mengyuan ;
Ventura, Andrea ;
Hayashi, Juliano Grigoleto ;
Poletti, Francesco ;
Yao, Shunchun ;
Ren, Wei .
SENSORS AND ACTUATORS B-CHEMICAL, 2022, 363
[10]   Quartz-enhanced photoacoustic spectroscopy [J].
Kosterev, AA ;
Bakhirkin, YA ;
Curl, RF ;
Tittel, FK .
OPTICS LETTERS, 2002, 27 (21) :1902-1904