A large Stokes shift probe based enhanced ICT strategy for Hg2+-detection in cancer cells and zebrafish

被引：8

作者：

Meng, Xiangying ^{[1
]}

Wang, Junbin ^{[1
]}

Li, Xin ^{[1
]}

Sun, Qi ^{[2
,3
]}

Tu, Qidong ^{[1
]}

Liu, Xiuhong ^{[1
]}

He, Haifeng ^{[1
]}

Zhao, Feng ^{[1
]}

机构：

[1] Jiangxi Sci & Technol Normal Univ, Sch Chem & Chem Engn, Jiangxi Engn Lab Waterborne, Nanchang 330013, Jiangxi, Peoples R China

[2] Wuhan Inst Technol, Key Lab Green Chem Proc, Minist Educ, Wuhan 430205, Peoples R China

[3] Wuhan Inst Technol, Sch Chem & Environm Engn, Wuhan 430205, Peoples R China

来源：

MICROCHEMICAL JOURNAL | 2021年 / 169卷

基金：

中国国家自然科学基金;

关键词：

2; 1; 3-Benzothiadiazole; Rhodanine-3-acetic acid; Hg2+; Cancer cells and zebrafish; FLUORESCENT SENSOR; AQUEOUS-MEDIA; LIVING CELLS; HG2+ SENSOR; MERCURY; IONS; CHEMOSENSOR; DERIVATIVES; CU2+; SYSTEM;

D O I：

10.1016/j.microc.2021.106551

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Development of a probe with novel fluorophore for Hg2+ detection in organism with high selectivity and sensitivity, is of great interest but remains a great challenge. Hence, in this work, a new probe (BTD-RDA), which contained a conjugated 2,1,3-benzothiadiazole structure as the fluorophore and Rhodanine-3-acetic acid moiety as the receptor, was developed for Hg2+ detection with good binding constant, low Limit of Detection (0.393 mu M) and high selectivity and sensitivity. Moreover, the plausible recognition pattern was derived from DFT calculations, and 1H NMR titration. Impressively, BTD-RDA was successfully employed in cancer cells and zebrafish for Hg2+ detection, indicating that it can be potentially applied for Hg2+ sensing in biology fields.

引用

页数：7

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