Dual inhibition of arachidonic acid pathway by mulberry leaf extract

被引：32

作者：

Chauhan, Seema ^{[1
]}

Devi, Uma ^{[2
]}

Kumar, Venkatesh R. ^{[1
]}

Kumar, Vikas ^{[3
]}

Anwar, Firoz ^{[4
]}

Kaithwas, Gaurav ^{[2
]}

机构：

[1] Babasaheb Bhimrao Ambedkar Univ,Raebareli Rd, SB&BT, Dept Appl Plant Sci, Lucknow 226025, Uttar Pradesh, India

[2] Babasaheb Bhimrao Ambedkar Univ, SB&BT, Dept Pharmaceut Sci, Lucknow 226025, Uttar Pradesh, India

[3] SHIATS Deemed Univ, FHMSIASM, Dept Pharmaceut Sci, Allahabad 211007, Uttar Pradesh, India

[4] Sidharatha Inst Pharm, Dehra Dun 248001, Uttar Pradesh, India

来源：

INFLAMMOPHARMACOLOGY | 2015年 / 23卷 / 01期

关键词：

Adjuvant arthritis; Cyclooxygenase; Inflammation; Lipoxygenase; Morus alba; ACETIC ACID; FIXED OIL; ARTHRITIS; CARRAGEENAN; CYTOKINES; MODELS; JOINT; EDEMA; RATS;

D O I：

10.1007/s10787-014-0223-y

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The present work investigates the anti-inflammatory, analgesic and antipyretic activity of methanolic extract of mulberry leaves of variety S-1, S-13 and S-146. The S-146 extract was further evaluated for its efficacy against adjuvant arthritis in albino rats followed by inhibitory potential for COX 1, COX 2 and 5 LOX. The HPLC analysis enumerated the presence of morin, reversterol, scopoletin and 7-hydroxy coumarin as the major constituents. The anti-inflammatory, antipyretic and analgesic activity observed in the present experiment could be accredited to the dual inhibition in the AA pathway. The inhibition of COX and LOX enzymes could be imparted to the presence of resveraterol, morin, scopoletin and 7-hydroxy coumarin.

引用

页码：65 / 70

页数：6

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