Management of primary central nervous system lymphoma

被引：7

作者：

Royer-Perron, Louis ^{[1
,3
,4
]}

Hoang-Xuan, Khe ^{[2
,3
,4
]}

机构：

[1] Hop Pierre Boucher, Longueuil, PQ, Canada

[2] CNRS, INSERM, Inst Cerveau & Moelle Epiniere ICM, UMR 7225,U1127, Paris, France

[3] UPMC Univ Paris 06, Sorbonne Univ, Hop Univ La Pitie Salpetriere, AP HP,Serv Neurol, 2 Mazarin, F-75013 Paris, France

[4] LOC Network, F-75561 Paris 13, France

来源：

PRESSE MEDICALE | 2018年 / 47卷 / 11-12期

关键词：

PRIMARY CNS LYMPHOMA; HIGH-DOSE METHOTREXATE; STEM-CELL TRANSPLANTATION; WHOLE-BRAIN RADIOTHERAPY; RECURRENT PRIMARY CNS; NON-HODGKINS-LYMPHOMA; INTERNATIONAL EXTRANODAL LYMPHOMA; MULTICENTER PHASE-II; LONG-TERM SURVIVAL; PRIMARY VITREORETINAL LYMPHOMA;

D O I：

10.1016/j.lpm.2018.04.016

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A rare tumor, primary central nervous system lymphoma can affect immunocompetent and immunocompromised patients. While sensitive to radiotherapy or chemotherapy crossing the blood-brain barrier, it often recurs. Modern treatment consists of high-dose methotrexate-based induction chemotherapy, often followed by consolidation with either radiotherapy or further chemotherapy. Neurotoxicity is however a concern with radiotherapy, especially for patients older than 60 years. The benefit of the addition of rituximab to chemotherapy is unclear. Targeted therapies and immunotherapy have been effect2ive in some patients and are tested on a larger scale. Survival has improved in the last decade, but remains poor in older patients.

引用

页码：E215 / E246

页数：32

共 272 条

[1] Primary central nervous system lymphoma: The Memorial Sloan-Kettering Cancer Center prognostic model [J].

Abrey, Lauren E. ;

Ben-Porat, Leah ;

Panageas, Katherine S. ;

Yahalom, Joachim ;

Berkey, Brian ;

Curran, Walter ;

Schultz, Christopher ;

Leibel, Steven ;

Nelson, Diana ;

Mehta, Minesh ;

DeAngelis, Lisa M. .

JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (36) :5711-5715

[2] Intensive methotrexate and cytarabine followed by high-dose chemotherapy with autologous stem-cell rescue in patients with newly diagnosed primary CNS lymphoma: An intent-to-treat analysis [J].

Abrey, LE ;

Moskowitz, CH ;

Mason, WP ;

Crump, M ;

Stewart, D ;

Forsyth, P ;

Paleologos, N ;

Correa, DD ;

Anderson, ND ;

Caron, D ;

Zelenetz, A ;

Nimer, SD ;

DeAngelis, LM .

JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (22) :4151-4156

[3] Report of an international workshop to standardize baseline evaluation and response criteria for primary CNS lymphoma [J].

Abrey, LE ;

Batchelor, TT ;

Ferreri, AJM ;

Gospodarowicz, M ;

Pulczynski, EJ ;

Zucca, E ;

Smith, JR ;

Korfel, A ;

Soussain, C ;

DeAngelis, LM ;

Neuwelt, EA ;

O'Neill, BP ;

Thiel, E ;

Shenkier, T ;

Graus, F ;

van den Bent, M ;

Seymour, JF ;

Poortmans, P ;

Armitage, JO ;

Cavalli, F .

JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (22) :5034-5043

[4] Long-term survival in primary CNS lymphoma [J].

Abrey, LE ;

DeAngelis, LM ;

Yahalom, J .

JOURNAL OF CLINICAL ONCOLOGY, 1998, 16 (03) :859-863

[5] Treatment for primary CNS lymphoma: The next step [J].

Abrey, LE ;

Yahalom, J ;

DeAngelis, LM .

JOURNAL OF CLINICAL ONCOLOGY, 2000, 18 (17) :3144-3150

[6] Differences between glioblastomas and primary central nervous system lymphomas in 1H-magnetic resonance spectroscopy [J].

Aburano, Hiroyuki ;

Ueda, Fumiaki ;

Yoshie, Yuichi ;

Matsui, Osamu ;

Nakada, Mitsutoshi ;

Hayashi, Yutaka ;

Gabata, Toshifumi .

JAPANESE JOURNAL OF RADIOLOGY, 2015, 33 (07) :392-403

[7] Upfront thiotepa, busulfan, cyclophosphamide, and autologous stem cell transplantation for primary CNS lymphoma: a single centre experience [J].

Alimohamed, Nimira ;

Daly, Andrew ;

Owen, Carolyn ;

Duggan, Peter ;

Stewart, Douglas A. .

LEUKEMIA & LYMPHOMA, 2012, 53 (05) :862-867

[8] Patterns of relapse in primary central nervous system lymphoma: inferences regarding the role of the neuro-vascular unit and monoclonal antibodies in treating occult CNS disease [J].

Ambady, Prakash ;

Fu, Rongwei ;

Netto, Joao Prola ;

Kersch, Cymon ;

Firkins, Jenny ;

Doolittle, Nancy D. ;

Neuwelt, Edward A. .

FLUIDS AND BARRIERS OF THE CNS, 2017, 14

[9] Blood-Brain Barrier Disruption and Intra-Arterial Methotrexate-Based Therapy for Newly Diagnosed Primary CNS Lymphoma: A Multi-Institutional Experience [J].

Angelov, Lilyana ;

Doolittle, Nancy D. ;

Kraemer, Dale F. ;

Siegal, Tali ;

Barnett, Gene H. ;

Peereboom, David M. ;

Stevens, Glen ;

McGregor, John ;

Jahnke, Kristoph ;

Lacy, Cynthia A. ;

Hedrick, Nancy A. ;

Shalom, Edna ;

Ference, Sandra ;

Bell, Susan ;

Sorenson, Lisa ;

Tyson, Rose Marie ;

Haluska, Marianne ;

Neuwelt, Edward A. .

JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (21) :3503-3509

[10] Advantages of Dose-Dense Methotrexate Protocol for Primary Central Nervous System Lymphoma: Comparison of Two Different Protocols at a Single Institution [J].

Aoki, Hiroshi ;

Ogura, Ryosuke ;

Tsukamoto, Yoshihiro ;

Okada, Masayasu ;

Natsumeda, Manabu ;

Isogawa, Mizuho ;

Yoshida, Seiichi ;

Fujii, Yukihiko .

NEUROLOGIA MEDICO-CHIRURGICA, 2013, 53 (11) :797-804

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