Surface-Enhanced Raman Spectroscopy Detection of Cerebrospinal Fluid Glucose Based on the Optofluidic In-Fiber-Integrated Composites of Graphene Oxide, Silver Nanoparticles, and 4-Mercaptophenylboronic Acid

被引：17

作者：

Gao, Danheng ^{[1
]}

Yang, Xinghua ^{[1
]}

Luo, Meng ^{[1
]}

Teng, Pingping ^{[1
]}

Zhang, Haoxin ^{[1
]}

Liu, Zhihai ^{[1
]}

Gao, Shuai ^{[1
]}

Li, Zhanao ^{[1
]}

Wen, Xingyue ^{[1
]}

Yuan, Libo ^{[1
,2
]}

Li, Kang ^{[3
]}

Bowkett, Mark ^{[3
]}

Copner, Nigel ^{[3
]}

机构：

[1] Harbin Engn Univ, Coll Sci, Key Lab In Fiber Integrated Opt, Minist Educ, Harbin 150001, Peoples R China

[2] Guilin Univ Elect Technol, Photon Res Ctr, Guilin 541004, Peoples R China

[3] Univ South Wales, Fac Comp Engn & Sci, Wireless & Optoelect Res & Innovat Ctr, Pontypridd CF37 1DL, M Glam, Wales

来源：

ACS APPLIED NANO MATERIALS | 2021年 / 4卷 / 10期

基金：

中国国家自然科学基金; 国家重点研发计划; 中央高校基本科研业务费专项资金资助;

关键词：

in-fiber Raman sensor; optofluidic microstructured optical fiber; self-assembled composite SERS substrate; graphene oxide/silver nanoparticles/4-mercaptophenylboronic acid; online detection; cerebrospinal fluid glucose detection; SERS; FABRICATION;

D O I：

10.1021/acsanm.1c02216

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

In this work, a self-assembled surface-enhanced Raman scattering (SERS) sensor based on an optofluidic microstructured hollow fiber (MHF) integrated composites of graphene oxide (GO), silver nanoparticles (Ag NPs), and 4-mercaptophenylboronic acid (4-MPBA) as a glucose detection device was proposed. This SERS substrate is specific to glucose and grows on the outside of the core of MHF. Here, the MHF has a microchannel, where a suspended core was attached. In the microchannel, the trace sample solution was interacted with the SERS substrate, realizing the Raman online sensing detection of trace cerebrospinal fluid glucose. In the range of 0.5-10 mmol/L, the results present that detection of the glucose concentration shows good linearity without external interference. Meanwhile, this type of rapid, online, and label-free SERS sensor of glucose shows the ability to detect excessive glucose content in the actual cerebrospinal fluid environment of the Sprague-Dawley rats, providing a simple detection method for meningitis, meningeal multiple malignant tumor metastasis, and related diseases caused by abnormal glucose content in cerebrospinal fluid.

引用

页码：10784 / 10790

页数：7

共 25 条

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