Retrovirus Restriction by TRIM5α: RINGside at a Cage Fight

被引：5

作者：

Sundquist, Wesley I. ^{[1
]}

Pornillos, Owen ^{[2
]}

机构：

[1] Univ Utah, Dept Biochem, Salt Lake City, UT 84112 USA

[2] Univ Virginia, Dept Mol Physiol & Biol Phys, Charlottesville, VA 22903 USA

来源：

CELL HOST & MICROBE | 2018年 / 24卷 / 06期

关键词：

TRIM5;

D O I：

10.1016/j.chom.2018.11.013

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The restriction factor TRIM5 alpha recognizes incoming retroviral capsids and blocks virus replication. In this issue of Cell Host & Microbe, Fletcher et al. (2018) show how the TRIM5 alpha RING domain mediates formation of various ubiquitin conjugates that differentially regulate TRIM5 alpha turnover, inhibition of viral reverse transcription, and innate immune activation.

引用

页码：751 / 753

页数：3

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