Hypochlorous Acid Activating MB-O to Release Methylene Blue for Photodegrading of Aβ Aggregates

被引：3

作者：

Bao, Xinlu ^{[1
]}

Yao, Yusi ^{[1
]}

Xu, Yunze ^{[1
]}

Shen, Yang ^{[1
]}

Lv, Guanglei ^{[1
]}

Zhao, Dian ^{[1
]}

Li, Chunxia ^{[1
,2
]}

机构：

[1] Zhejiang Normal Univ, Key Lab, Minist Educ Adv Catalysis Mat, Jinhua 321004, Zhejiang, Peoples R China

[2] Shandong Univ, Inst Mol Sci & Engn, Qingdao 266237, Shandong, Peoples R China

来源：

ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE | 2021年 / 647卷 / 20-21期

基金：

中国国家自然科学基金;

关键词：

fluorescence; methylene blue; hypochlorous acid; amyloid beta-peptides; Alzheimer's disease; ALZHEIMERS-DISEASE; MYELOPEROXIDASE; INHIBITION; PEPTIDES; CELLS;

D O I：

10.1002/zaac.202100253

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Amyloid-beta (A beta) aggregates are one of biomarkers of Alzheimer's disease (AD). It is well known that A beta aggregates display neurotoxicty or cytotoxicity to neurons. Thus, degrading A beta aggregates is crucial for exploring the treatment of AD. Moreover, the excessive production of HOCl in the AD brain is an important feature of the disease. Herein, a novel compound MB-O based on methylene blue (MB) skeleton was designed and synthesized. The probe MB-O can specifically react with HOCl, releasing the fluorophore MB with strong fluorescence intensity increase. More importantly, the released MB is capable of degrading A beta aggregates under red light irradiation.

引用

页码：1992 / 1996

页数：5

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