Targeting Muscarinic Acetylcholine Receptors for the Treatment of Psychiatric and Neurological Disorders

被引：100

作者：

Moran, Sean P. ^{[1
,2
,3
]}

Maksymetz, James ^{[2
,3
]}

Conn, P. Jeffrey ^{[1
,2
,3
]}

机构：

[1] Vanderbilt Univ, Vanderbilt Brain Inst, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Dept Pharmacol, Nashville, TN 37232 USA

[3] Vanderbilt Univ, Vanderbilt Ctr Neurosci Drug Discovery, Nashville, TN 37232 USA

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2019年 / 40卷 / 12期

基金：

美国国家卫生研究院; 加拿大健康研究院;

关键词：

POSITIVE ALLOSTERIC MODULATORS; VIVO TOOL COMPOUND; M-4; RECEPTOR; AGONIST; M1; DOPAMINE; XANOMELINE; PAM; RAT; CNS;

D O I：

10.1016/j.tips.2019.10.007

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Muscarinic acetylcholine receptors (mAChR) play important roles in regulating complex behaviors such as cognition, movement, and reward, making them ideally situated as potential drug targets for the treatment of several brain disorders. Recent advances in the discovery of subtype-selective allosteric modulators for mAChRs has provided an unprecedented opportunity for highly specific modulation of signaling by individual mAChR subtypes in the brain Recently, mAChR allosteric modulators have entered clinical development for Alzheimer's disease (AD) and schizophrenia, and have potential utility for other brain disorders. However, mAChR allosteric modulators can display a diverse array of pharmacological properties, and a more nuanced understanding of the mAChR will be necessary to best translate predinical findings into successful clinical treatments.

引用

页码：1006 / 1020

页数：15

共 111 条

[1] Selective cognitive dysfunction in acetylcholine M1 muscarinic receptor mutant mice [J].

Anagnostaras, SG ;

Murphy, GG ;

Hamilton, SE ;

Mitchell, SL ;

Rahnama, NP ;

Nathanson, NM ;

Silva, AJ .

NATURE NEUROSCIENCE, 2003, 6 (01) :51-58

[2] Deletion of the M5 muscarinic acetylcholine receptor attenuates morphine reinforcement and withdrawal but not morphine analgesia [J].

Basile, AS ;

Fedorova, I ;

Zapata, A ;

Liu, XG ;

Shippenberg, T ;

Duttaroy, A ;

Yamada, M ;

Wess, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (17) :11452-11457

[3] Classics in Chemical Neuroscience: Xanomeline [J].

Bender, Aaron M. ;

Jones, Carrie K. ;

Lindsley, Craig W. .

ACS CHEMICAL NEUROSCIENCE, 2017, 8 (03) :435-443

[4] Muscarinic M5 receptors modulate ethanol seeking in rats [J].

Berizzi, Alice E. ;

Perry, Christina J. ;

Shackleford, David M. ;

Lindsley, Craig W. ;

Jones, Carrie K. ;

Chen, Nicola A. ;

Sexton, Patrick M. ;

Christopoulos, Arthur ;

Langmead, Christopher J. ;

Lawrence, Andrew J. .

NEUROPSYCHOPHARMACOLOGY, 2018, 43 (07) :1510-1517

[5]

Birks J, 2006, COCHRANE DB SYST REV, DOI [10.1002/14651858.CD001190.pub2, 10.1002/14651858.CD001190.pub3]

[6] Effects of xanomeline, a selective muscarinic receptor agonist, on cognitive function and behavioral symptoms in Alzheimer disease [J].

Bodick, NC ;

Offen, WW ;

Levey, AI ;

Cutler, NR ;

Gauthier, SG ;

Satlin, A ;

Shannon, HE ;

Tollefson, GD ;

Rasmussen, K ;

Bymaster, FP ;

Hurley, DJ ;

Potter, WZ ;

Paul, SM .

ARCHIVES OF NEUROLOGY, 1997, 54 (04) :465-473

[7] Reducing the Health Consequences of Opioid Addiction in Primary Care [J].

Bowman, Sarah ;

Eiserman, Julie ;

Beletsky, Leo ;

Stancliff, Sharon ;

Bruce, R. Douglas .

AMERICAN JOURNAL OF MEDICINE, 2013, 126 (07) :565-571

[8] Bitopic Binding Mode of an M1 Muscarinic Acetylcholine Receptor Agonist Associated with Adverse Clinical Trial Outcomes [J].

Bradley, Sophie J. ;

Molloy, Colin ;

Bundgaard, Christoffer ;

Mogg, Adrian J. ;

Thompson, Karen J. ;

Dwomoh, Louis ;

Sanger, Helen E. ;

Crabtree, Michael D. ;

Brooke, Simon M. ;

Sexton, Patrick M. ;

Felder, Christian C. ;

Christopoulos, Arthur ;

Broad, Lisa M. ;

Tobin, Andrew B. ;

Langmead, Christopher J. .

MOLECULAR PHARMACOLOGY, 2018, 93 (06) :645-656

[9] M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss [J].

Bradley, Sophie J. ;

Bourgognon, Julie-Myrtille ;

Sanger, Helen E. ;

Verity, Nicholas ;

Mogg, Adrian J. ;

White, David J. ;

Butcher, Adrian J. ;

Moreno, Julie A. ;

Molloy, Colin ;

Macedo-Hatch, Timothy ;

Edwards, Jennifer M. ;

Wess, Jurgen ;

Pawlak, Robert ;

Read, David J. ;

Sexton, Patrick M. ;

Broad, Lisa M. ;

Steinert, Joern R. ;

Mallucci, Giovanna R. ;

Christopoulos, Arthur ;

Felder, Christian C. ;

Tobin, Andrew B. .

JOURNAL OF CLINICAL INVESTIGATION, 2017, 127 (02) :487-499

[10] Centrally Active Allosteric Potentiators of the M4 Muscarinic Acetylcholine Receptor Reverse Amphetamine-Induced Hyperlocomotor Activity in Rats [J].

Brady, Ashley E. ;

Jones, Carrie K. ;

Bridges, Thomas M. ;

Kennedy, J. Phillip ;

Thompson, Analisa D. ;

Heiman, Justin U. ;

Breininger, Micah L. ;

Gentry, Patrick R. ;

Yin, Huiyong ;

Jadhav, Satyawan B. ;

Shirey, Jana K. ;

Conn, P. Jeffrey ;

Lindsley, Craig W. .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2008, 327 (03) :941-953

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