Epidermal growth factor receptor (EGFR) expression in patients with laryngeal squamous cell carcinoma

被引：14

作者：

Kontic, Mirko ^{[1
]}

Milovanovic, Jovica ^{[2
]}

Colovic, Zavisa ^{[1
]}

Poljak, Nikola Kolja ^{[1
]}

Sundov, Zeljko ^{[3
]}

Sucic, Ante ^{[4
]}

Pesutic-Pisac, Valdi ^{[5
]}

机构：

[1] Univ Split, Sch Med, Univ Hosp Ctr Split, ENT Dept, Split, Croatia

[2] Univ Belgrade, Sch Med, Belgrade, Serbia

[3] Univ Split, Sch Med, Univ Hosp Ctr Split, Dept Internal Med, Split, Croatia

[4] Univ Hosp Ctr Split, ENT Dept, Split, Croatia

[5] Univ Split, Sch Med, Univ Hosp Ctr Split, Dept Pathol, Split, Croatia

来源：

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY | 2015年 / 272卷 / 02期

关键词：

Epidermal growth factor receptor; EGFR; Squamous cell carcinoma; Larynx; Survival; TISSUE MICROARRAY; GLOTTIC CANCER; FACTOR-ALPHA; NECK-CANCER; HEAD; MARKERS; PROTEIN; LESIONS;

D O I：

10.1007/s00405-014-3323-9

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

To assess the epidermal growth factor receptor (EGFR) correlation with histopathologic and clinical characteristics of laryngeal squamous cell carcinoma (SCC) and the impact of EGFR overexpression on patient survival. This retrospective study included 185 SCC patients treated at Clinical Department of ENT, Head and Neck Surgery, Split University Hospital Center between January 1, 2000 and December 31, 2009. A statistically significant correlation (p < 0.001) was recorded between the level of EGFR expression and SCC histopathologic grade, stage, metastasizing potential, relapsing potential, and patient survival. Kaplan-Meier survival curve yielded a statistically significant difference (chi (2) = 75.05; p < 0.001) among the four patient groups with different levels of EGFR expression. The higher the level of EGFR expression, the poorer is the patient prognosis and survival. In our study, expression of EGFR as a biomarker showed a potential predictive value in laryngeal SCC.

引用

页码：401 / 405

页数：5

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