Clinical standards for drug-susceptible pulmonary TB

被引：28

作者：

Akkerman, O. W. ^{[1
,2
]}

Duarte, R. ^{[3
,4
]}

Tiberi, S. ^{[5
]}

Schaaf, H. S. ^{[6
]}

Lange, C. ^{[7
,8
,9
,10
]}

Alffenaar, J. W. C. ^{[11
,12
,13
]}

Denholm, J. ^{[14
]}

Carvalho, A. C. C. ^{[15
]}

Bolhuis, M. S. ^{[16
]}

Borisov, S. ^{[17
]}

Bruchfeld, J. ^{[18
,19
]}

Cabibbe, A. M. ^{[20
]}

Caminero, J. A. ^{[21
,22
]}

Carvalho, I ^{[23
]}

Chakaya, J. ^{[24
,25
]}

Centis, R. ^{[26
]}

Dalcomo, M. P. ^{[27
]}

Ambrosio, L. D. ^{[28
]}

Dedicoat, M. ^{[29
]}

Dheda, K. ^{[30
,31
,32
,33
]}

Dooley, K. E. ^{[34
]}

Furin, J. ^{[35
]}

Garcia-Garcia, J-M ^{[36
]}

van Hest, N. A. H. ^{[2
,37
]}

de Jong, B. C. ^{[38
]}

Kurhasani, X. ^{[39
]}

Martson, A. G. ^{[40
]}

Mpagama, S. ^{[41
,42
]}

Torrico, M. Munoz ^{[43
]}

Nunes, E. ^{[44
,45
]}

Ong, C. W. M. ^{[46
,47
,48
]}

Palmero, D. J. ^{[49
]}

Ruslami, R. ^{[50
,51
]}

Saktiawati, A. M., I ^{[52
,53
]}

Semuto, C. ^{[54
]}

Silva, D. R. ^{[55
]}

Singla, R. ^{[56
]}

Solovic, I ^{[57
]}

Srivastava, S. ^{[58
]}

de Steenwinkel, J. E. M. ^{[59
]}

Story, A. ^{[60
,61
]}

Sturkenboom, M. G. G. ^{[16
]}

Tadolini, M. ^{[62
,63
]}

Udwadia, Z. F. ^{[64
]}

Verhage, A. R. ^{[65
]}

Zellweger, J. P. ^{[66
]}

Migliori, G. B. ^{[26
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, TB Ctr Beatrixoord, Haren, Netherlands

[2] Univ Groningen, Univ Med Ctr Groningen, Dept Pulm Dis & TB, Groningen, Netherlands

[3] Ctr Hosp Vila Nova de Gaia Espinho, Vila Nova De Gaia, Portugal

[4] Univ Porto, Inst Ciencias Biomed Abel Saalazar, Inst Saude Publ, Unidade Invest Clin,ARS Norte, Porto, Portugal

[5] Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, Div Infect,Royal London Hosp,Barts Hlth NHS Trust, London, England

[6] Stellenbosch Univ, Fac Med & Hlth Sci, Dept Paediat & Child Hlth, Desmond Tutu TB Ctr, Cape Town, South Africa

[7] Res Ctr Borstel, Div Clin Infect Dis Res, Borstel, Germany

[8] German Ctr Infect Res DZIF, Clin TB Unit, Borstel, Germany

[9] Univ Lubeck, Resp Med & Int Hlth, Lubeck, Germany

[10] Baylor Coll Med, Dept Pediat, Immigrant & Global Hlth, Global TB Program,Texas Childrens Hosp, Houston, TX 77030 USA

[11] Univ Sydney, Sydney Inst Infect Dis, Sydney, NSW, Australia

[12] Univ Sydney, Sch Pharm, Fac Med & Hlth, Sydney, NSW, Australia

[13] Westmead Hosp, Sydney, NSW, Australia

[14] Univ Melbourne, Dept Infect Dis, Melbourne Hlth, Victorian TB Program,Peter Doherty Inst Infect &, Melbourne, Vic, Australia

[15] Fundacao Oswaldo Cruz FIOCRUZ, Inst Oswaldo Cruz, Lab Inovacoes Terapias Ensino & Bioprod, Rio De Janeiro, RJ, Brazil

[16] Univ Groningen, Univ Med Ctr Groningen, Dept Clin Pharm & Pharmacol, Groningen, Netherlands

[17] Moscow Res & Clin Ctr TB Control, Moscow, Russia

[18] Karolinska Inst, Dept Med, Div Infect Dis, Stockholm, Sweden

[19] Karolinska Univ Hosp, Dept Infect Dis, Stockholm, Sweden

[20] Ist Sci San Raffaele, Ist Ricovero & Cura Carattere Sci IRCCS, Div Immunol Transplantat & Infect Dis, Emerging Bacterial Pathogens Unit, Milan, Italy

[21] Univ Gen Hosp Gran Canaria Dr Negrin, Dept Pneumol, Las Palmas Gran Canaria, Spain

[22] ALOSA Act Learning Sanit Aspects TB Acad, Las Palmas Gran Canaria, Spain

[23] Vila Nova de Gaia Hosp Ctr, Vila Nova de Gaia Outpatient TB Ctr, Pediat Dept, Vila Nova De Gaia, Portugal

[24] Kenyatta Univ, Dept Med Therapeut & Dermatol, Nairobi, Kenya

[25] Univ Liverpool Liverpool Sch Trop Med, Dept Clin Sci, Liverpool, Merseyside, England

[26] Ist Clin Sci Maugeri IRCCS, Serv Epidemiol Clin Malattie Resp, Tradate, Italy

[27] Fiocruz MS, Reference Ctr Helio Fraga, Rio De Janeiro, Brazil

[28] Publ Hlth Consulting Grp, Lugano, Switzerland

[29] Univ Hosp Birmingham NHS Fdn Trust, Heartlands Hosp, Dept Infect Dis, Birmingham, W Midlands, England

[30] Univ Cape Town, Ctr Lung Infect, Dept Med, Div Pulmonol, Cape Town, South Africa

[31] Univ Cape Town, Immun Unit, Dept Med, Div Pulmonol, Cape Town, South Africa

[32] Univ Cape Town, South African Med Res Council Ctr Study Antimicro, Cape Town, South Africa

[33] London Sch Hyg & Trop Med, Fac Infect & Trop Dis, London, England

[34] Johns Hopkins, Ctr TB Res, Baltimore, MD USA

[35] Harvard Med Sch, Dept Global Hlth & Social Med, Boston, MA 02115 USA

[36] TB Res Programme SEPAR, E-08029 Barcelona, Spain

[37] Municipal Publ Hlth Serv Groningen, Groningen, Netherlands

[38] Inst Trop Med, Dept Biomed Sci, Mycobacteriol Unit, Antwerp, Belgium

[39] UBT Higher Educ Inst Prishtina, Pristina, Kosovo

[40] Univ Liverpool, Dept Pharmacol & Therapeut, Antimicrobial Pharmacodynam & Therapeut, Liverpool, Merseyside, England

[41] Kilimanjaro Christian Med Univ Coll, Moshi, Tanzania

[42] Kibongoto Infect Dis Hosp, Siha, Kilimanjaro, Tanzania

[43] Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Clin TB, Mexico City, DF, Mexico

[44] Cent Hosp Maputo, Dept Pulmonol, Maputo, Mozambique

[45] Eduardo Mondlane Univ, Fac Med, Maputo, Mozambique

[46] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Infect Dis Translat Res Programme, Singapore, Singapore

[47] Natl Univ Singapore, Inst Hlth Innovat & Technol iHealthtech, Singapore, Singapore

[48] Natl Univ Singapore Hosp, Dept Med, Div Infect Dis, Singapore, Singapore

[49] Univ Fed Rio Grande do Sul, Fac Med, Porto Alegre, RS, Brazil

[50] Univ Padjadjaran, Dept Biomed Sci, Fac Med, Bandung, Indonesia

来源：

INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE | 2022年 / 26卷 / 07期

关键词：

pulmonary TB; management; diagnosis; treatment; education; rehabilitation; clinical standards; MULTIDRUG-RESISTANT TUBERCULOSIS; PREVENTION/INFECTIOUS DISEASES SOCIETY; AMERICAN THORACIC SOCIETY/CENTERS; PRACTICE GUIDELINES TREATMENT; MYCOBACTERIUM-TUBERCULOSIS; TREATMENT OUTCOMES; SPUTUM COLLECTION; END TB; MANAGEMENT; ADHERENCE;

D O I：

10.5588/ijtld.22.0228

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

BACKGROUND: The aim of these clinical standards is to provide guidance on 'best practice' for diagnosis, treatment and management of drug-susceptible pulmonary TB (PTB). METHODS: A panel of 54 global experts in the field of TB care, public health, microbiology, and pharmacology were identified; 46 participated in a Delphi process. A 5point Likert scale was used to score draft standards. The final document represents the broad consensus and was approved by all 46 participants. RESULTS: Seven clinical standards were defined: Standard 1, all patients (adult or child) who have symptoms and signs compatible with PTB should undergo investigations to reach a diagnosis; Standard 2, adequate bacteriological tests should be conducted to exclude drug-resistant TB; Standard 3, an appropriate regimen recommended by WHO and national guidelines for the treatment of PTB should be identified; Standard 4, health education and counselling should be provided for each patient starting treatment; Standard 5, treatment monitoring should be conducted to assess adherence, follow patient progress, identify and manage adverse events, and detect development of resistance; Standard 6, a recommended series of patient examinations should be performed at the end of treatment; Standard 7, necessary public health actions should be conducted for each patient. We also identified priorities for future research into PTB. CONCLUSION: These consensus-based clinical standards will help to improve patient care by guiding clinicians and programme managers in planning and implementation of locally appropriate measures for optimal person-centred treatment for PTB.

引用

页码：592 / 604

页数：13

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