A FoxL in the Smad house: activin regulation of FSH

被引：37
作者：
Coss, Djurdjica
Mellon, Pamela L.
Thackray, Varykina G. [1 ]
机构：
[1] Univ Calif San Diego, Ctr Reprod Sci & Med, Dept Reprod Med, La Jolla, CA 92093 USA
来源：
TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2010年 / 21卷 / 09期
关键词：
FOLLICLE-STIMULATING-HORMONE; GONADOTROPIN-RELEASING-HORMONE; BETA-SUBUNIT GENE; GROWTH-FACTOR-BETA; RAT ESTROUS-CYCLE; TRANSCRIPTIONAL ACTIVATION; FORKHEAD TRANSCRIPTION; SYNERGISTIC INDUCTION; PITUITARY-CELLS; IN-VITRO;
D O I：
10.1016/j.tem.2010.05.006
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Follicle-stimulating hormone (FSH), produced by pituitary gonadotrope cells, is required for maturation of ovarian follicles. The FSH beta subunit is the limiting factor for production of mature hormone and provides biological specificity. Activin dramatically induces FSH beta transcription and the secondary rise in FSH, important for follicular development, is dependent on this induction. Thus, regulation of FSH beta levels by activin is crucial for female reproductive fitness. This review discusses activin signaling pathways, transcription factors and FSH beta promoter elements required for activin responsiveness. Because FoxL2, a forkhead transcription factor, was recently shown to be instrumental in relaying activin signaling to the FSH beta promoter, we focus in this paper on its role and the inter-relatedness of several key players in activin responsiveness on the FSH beta promoter.
引用
收藏
页码：562 / 568
页数：7
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