Sesquiterpenes from Syneilesis palmata and their cytotoxicity against human cancer cell lines in vitro

被引：32
|
作者：
Lee, KH
Choi, SU
Lee, KR
机构：
[1] Sungkyunkwan Univ, Coll Pharm, Nat Prod Lab, Suwon 440746, South Korea
[2] Korea Res Inst Chem Technol, Taejon 305600, South Korea
来源：
ARCHIVES OF PHARMACAL RESEARCH | 2005年 / 28卷 / 03期
关键词：
Syneilesis palmata; terpenoid; oplopanone; glycoside; cytotoxicity;
D O I：
10.1007/BF02977792
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The chromatographic separation of the MeOH extract from the aerial parts of Syneilesis palmata led to the isolation of a new sesquiterpene glycoside 4, together with four known compounds. Their structures were characterized to be 4 beta,5 beta-epoxy-caryophill-8,(15)-ene (1), 3 beta-hydroxy-gultin-5-ene (2), 4 alpha,5 beta-dihydroxy-caryophill-8,(15)-ene (3), (-)-oplopan-4-one-10-alpha-O-beta-D-glucose (4) and 3-hexenyl-1-O-beta-D-glucopyranose (5), based on spectroscopic and chemical methods. Compound 2 showed moderate cytotoxicity against five human tumor cell lines in vitro with its ED50 values ranging from 5.90-10.83 mu g/mL.
引用
收藏
页码：280 / 284
页数：5
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