Therapeutic potential of cancer stem cells

被引：15
作者：
Yang, Chunguang [1 ]
Jin, Kunlin [2 ]
Tong, Yangping [3 ]
Cho, William Chi [4 ]
机构：
[1] Cent S Univ, Dept Otorhinolaryngol Head & Neck Surg, Xiangya Hosp, Changsha, Hunan, Peoples R China
[2] Univ N Texas, Hlth Sci Ctr, Dept Pharmacol & Neurosci, Ft Worth, TX USA
[3] Changsha Cent Hosp, Dept Neurol, Changsha, Hunan, Peoples R China
[4] Queen Elizabeth Hosp, Dept Clin Oncol, Kowloon, Hong Kong, Peoples R China
来源：
MEDICAL ONCOLOGY | 2015年 / 32卷 / 06期
关键词：
Cancer stem cells; Signaling pathway; Therapeutics; Epithelial-mesenchymal transition; NONCODING RNA; MYELOID-LEUKEMIA; SELF-RENEWAL; BETA-CATENIN; GENOMIC INSTABILITY; TUMOR-SUPPRESSOR; DOWN-REGULATION; OVARIAN-CANCER; LUNG-CANCER; WNT PATHWAY;
D O I：
10.1007/s12032-015-0619-6
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cancer stem cells (CSCs) play an important role in cancer growth, self-renewal, metastasis, recurrence and radio/chemotherapy. However, the underlying mechanisms remain elusive. In this review, we explore the roles of CSCs in cancer's relapse and progression and discuss the biomarkers of CSCs to predict clinical outcome and their diagnostic potential. The different approaches of CSC therapies are also reviewed, including cytotoxic, radiation, differentiation and targeting signaling pathways. We also discuss the challenge of targeting CSCs in cancer therapy. In addition, non-coding RNAs in CSC therapies are also discussed.
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收藏
页数：10
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