Therapeutic potential of cancer stem cells

被引：15
作者：
Yang, Chunguang [1 ]
Jin, Kunlin [2 ]
Tong, Yangping [3 ]
Cho, William Chi [4 ]
机构：
[1] Cent S Univ, Dept Otorhinolaryngol Head & Neck Surg, Xiangya Hosp, Changsha, Hunan, Peoples R China
[2] Univ N Texas, Hlth Sci Ctr, Dept Pharmacol & Neurosci, Ft Worth, TX USA
[3] Changsha Cent Hosp, Dept Neurol, Changsha, Hunan, Peoples R China
[4] Queen Elizabeth Hosp, Dept Clin Oncol, Kowloon, Hong Kong, Peoples R China
来源：
MEDICAL ONCOLOGY | 2015年 / 32卷 / 06期
关键词：
Cancer stem cells; Signaling pathway; Therapeutics; Epithelial-mesenchymal transition; NONCODING RNA; MYELOID-LEUKEMIA; SELF-RENEWAL; BETA-CATENIN; GENOMIC INSTABILITY; TUMOR-SUPPRESSOR; DOWN-REGULATION; OVARIAN-CANCER; LUNG-CANCER; WNT PATHWAY;
D O I：
10.1007/s12032-015-0619-6
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cancer stem cells (CSCs) play an important role in cancer growth, self-renewal, metastasis, recurrence and radio/chemotherapy. However, the underlying mechanisms remain elusive. In this review, we explore the roles of CSCs in cancer's relapse and progression and discuss the biomarkers of CSCs to predict clinical outcome and their diagnostic potential. The different approaches of CSC therapies are also reviewed, including cytotoxic, radiation, differentiation and targeting signaling pathways. We also discuss the challenge of targeting CSCs in cancer therapy. In addition, non-coding RNAs in CSC therapies are also discussed.
引用
收藏
页数：10
相关论文
共 97 条
[1]   Identification of Pancreatic Cancer Stem Cells and Selective Toxicity of Chemotherapeutic Agents [J].
Adikrisna, Rama ;
Tanaka, Shinji ;
Muramatsu, Shunsuke ;
Aihara, Arihiro ;
Ban, Daisuke ;
Ochiai, Takanori ;
Irie, Takumi ;
Kudo, Atsushi ;
Nakamura, Noriaki ;
Yamaoka, Shoji ;
Arii, Shigeki .
GASTROENTEROLOGY, 2012, 143 (01) :234-U448
[2]   Involvement of miRNAs in the Differentiation of Human Glioblastoma Multiforme Stem-Like Cells [J].
Aldaz, Beatriz ;
Sagardoy, Ainara ;
Nogueira, Lorena ;
Guruceaga, Elizabeth ;
Grande, Lara ;
Huse, Jason T. ;
Aznar, Maria A. ;
Diez-Valle, Ricardo ;
Tejada-Solis, Sonia ;
Alonso, Marta M. ;
Fernandez-Luna, Jose L. ;
Martinez-Climent, Jose A. ;
Malumbres, Raquel .
PLOS ONE, 2013, 8 (10)
[3]  
Androutsellis-Theotokis A, 2006, NATURE, V442, P823, DOI 10.1038/nature04940
[4]   The Wnt/β-catenin pathway in ovarian cancer: A review [J].
Arend, Rebecca C. ;
Londono-Joshi, Angelina I. ;
Straughn, J. Michael, Jr. ;
Buchsbaum, Donald J. .
GYNECOLOGIC ONCOLOGY, 2013, 131 (03) :772-779
[5]   Tumour CD133 mRNA expression and clinical outcome in surgically resected colorectal cancer patients [J].
Artells, R. ;
Moreno, I. ;
Diaz, T. ;
Martinez, F. ;
Gel, B. ;
Navarro, A. ;
Ibeas, R. ;
Moreno, J. ;
Monzo, M. .
EUROPEAN JOURNAL OF CANCER, 2010, 46 (03) :642-649
[6]   Differentiation Therapy: Targeting Human Renal Cancer Stem Cells with Interleukin 15 [J].
Azzi, Sandy ;
Bruno, Stefania ;
Giron-Michel, Julien ;
Clay, Denis ;
Devocelle, Aurore ;
Croce, Michela ;
Ferrini, Silvano ;
Chouaib, Salem ;
Vazquez, Aime ;
Charpentier, Bernard ;
Camussi, Giovanni ;
Azzarone, Bruno ;
Eid, Pierre .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2011, 103 (24) :1884-1898
[7]   Glioma stem cells promote radioresistance by preferential activation of the DNA damage response [J].
Bao, Shideng ;
Wu, Qiulian ;
McLendon, Roger E. ;
Hao, Yueling ;
Shi, Qing ;
Hjelmeland, Anita B. ;
Dewhirst, Mark W. ;
Bigner, Darell D. ;
Rich, Jeremy N. .
NATURE, 2006, 444 (7120) :756-760
[8]   Mining the Wnt pathway for cancer therapeutics [J].
Barker, Nick ;
Clevers, Hans .
NATURE REVIEWS DRUG DISCOVERY, 2006, 5 (12) :997-1014
[9]   Genomic instability may originate from imatinib-refractory chronic myeloid leukemia stem cells [J].
Bolton-Gillespie, Elisabeth ;
Schemionek, Mirle ;
Klein, Hans-Ulrich ;
Flis, Sylwia ;
Hoser, Grazyna ;
Lange, Thoralf ;
Nieborowska-Skorska, Margaret ;
Maier, Jacqueline ;
Kerstiens, Linda ;
Koptyra, Mateusz ;
Mueller, Martin C. ;
Modi, Hardik ;
Stoklosa, Tomasz ;
Seferynska, Ilona ;
Bhatia, Ravi ;
Holyoake, Tessa L. ;
Koschmieder, Steffen ;
Skorski, Tomasz .
BLOOD, 2013, 121 (20) :4175-4183
[10]   Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell [J].
Bonnet, D ;
Dick, JE .
NATURE MEDICINE, 1997, 3 (07) :730-737
12345678910