Exploring kinase inhibitors as therapies for human arenavirus infections

被引：9

作者：

Vela, Eric M. ^{[1
]}

Bowick, Gavin C. ^{[2
]}

Herzog, Norbert K. ^{[2
]}

Aronson, Judith F. ^{[2
]}

机构：

[1] BBRC, Columbus, OH 43201 USA

[2] Univ Texas Galveston, Med Branch, Ctr Biodef & Emerging Infect Dis, Inst Human Infect & Immun,Dept Pathol, Galveston, TX 77555 USA

来源：

FUTURE VIROLOGY | 2008年 / 3卷 / 03期

关键词：

antiviral therapeutics; arenavirus; hemorrhagic fever; kinase inhibitors; virology;

D O I：

10.2217/17460794.3.3.243

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Arenaviruses are rodent-borne RNA viruses, and some have the capacity to cause hemorrhagic fever and death in infected individuals and thus have been identified as a potential bioterrorism threat. Ribavirin and supportive care are currently the approved therapeutic options for individuals suffering from arenavirus-induced hemorrhagic fever. However, new research has suggested that immune plasma treatment or kinase inhibitors may provide a therapeutic option for treating arenavirus infections in humans. This article puts forth a perspective as to the potential use of kinase inhibitors as an antiviral therapeutic for arenavirus infections.

引用

页码：243 / 251

页数：9

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