Implementation Research for the Prevention of Mother-to-Child HIV Transmission in Sub-Saharan Africa: Existing Evidence, Current Gaps, and New Opportunities

被引:32
作者
Bhardwaj, Sanjana [1 ]
Carter, Bryan [2 ]
Aarons, Gregory A. [3 ]
Chi, Benjamin H. [4 ]
机构
[1] UNICEF, Pretoria, South Africa
[2] Icahn Sch Med Mt Sinai, New York, NY USA
[3] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA
[4] Univ N Carolina, Dept Obstet & Gynecol, Chapel Hill, NC 27590 USA
关键词
HIV; Implementation research; Prevention of mother-to-child HIV transmission; PMTCT; Africa; OPTION B PLUS; FAMILY-PLANNING-SERVICES; EARLY INFANT DIAGNOSIS; RAPID SCALE-UP; ANTIRETROVIRAL THERAPY; PREEXPOSURE PROPHYLAXIS; COMBINATION PREVENTION; REPRODUCTIVE HEALTH; CONTRACEPTIVE USE; POSTPARTUM WOMEN;
D O I
10.1007/s11904-015-0260-1
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Tremendous gains have been made in the prevention of mother-to-child HIV transmission (PMTCT) in sub-Saharan Africa. Ambitious goals for the "virtual elimination" of pediatric HIV appear increasingly feasible, driven by new scientific advances, forward-thinking health policy, and substantial donor investment. To fulfill this promise, however, rapid and effective implementation of evidence-based practices must be brought to scale across a diversity of settings. The discipline of implementation research can facilitate this translation from policy into practice; however, to date, its core principles and frameworks have been inconsistently applied in the field. We reviewed the recent developments in implementation research across each of the four "prongs" of a comprehensive PMTCT approach. While significant progress continues to be made, a greater emphasis on context, fidelity, and scalability-in the design and dissemination of study results-would greatly enhance current efforts and provide the necessary foundation for future evidence-based programs.
引用
收藏
页码:246 / 255
页数:10
相关论文
共 98 条
[1]   Risks and benefits of lifelong antiretroviral treatment for pregnant and breastfeeding women: a review of the evidence for the Option B plus approach [J].
Ahmed, Saeed ;
Kim, Maria H. ;
Abrams, Elaine J. .
CURRENT OPINION IN HIV AND AIDS, 2013, 8 (05) :474-489
[2]  
[Anonymous], 2013, IMPLEMENTATION RES H
[3]   Educational Intervention Increased Referrals to Allopathic Care by Traditional Healers in Three High HIV-Prevalence Rural Districts in Mozambique [J].
Audet, Carolyn M. ;
Salato, Jose ;
Blevins, Meridith ;
Amsalem, David ;
Vermund, Sten H. ;
Gaspar, Felisbela .
PLOS ONE, 2013, 8 (08)
[4]  
Baron D, 2015, 2015 C RETR OPP INF
[5]   AVOIDING TYPE-III ERRORS IN HEALTH-EDUCATION PROGRAM EVALUATIONS - A CASE-STUDY [J].
BASCH, CE ;
SLIEPCEVICH, EM ;
GOLD, RS ;
DUNCAN, DF ;
KOLBE, LJ .
HEALTH EDUCATION QUARTERLY, 1985, 12 (04) :315-331
[6]  
Bhardwaj S, 2014, SAMJ S AFR MED J, V104, P239, DOI [10.7196/SAMJ.7605, 10.7196/samj.7605]
[7]   Combination HIV Prevention Interventions: The Potential of Integrated Behavioral and Biomedical Approaches [J].
Brown, Jennifer L. ;
Sales, Jessica M. ;
DiClemente, Ralph J. .
CURRENT HIV/AIDS REPORTS, 2014, 11 (04) :363-375
[8]   Antiretroviral Drug Regimens to Prevent Mother-To-Child Transmission of HIV: A Review of Scientific, Program, and Policy Advances for Sub-Saharan Africa [J].
Chi, Benjamin H. ;
Stringer, Jeffrey S. A. ;
Moodley, Dhayendre .
CURRENT HIV/AIDS REPORTS, 2013, 10 (02) :124-133
[9]   Progress, Challenges, and New Opportunities for the Prevention of Mother-to-Child Transmission of HIV Under the US President's Emergency Plan for AIDS Relief [J].
Chi, Benjamin H. ;
Adler, Michelle R. ;
Bolu, Omotayo ;
Mbori-Ngacha, Dorothy ;
Ekouevi, Didier K. ;
Gieselman, Anna ;
Chipato, Tsungai ;
Luo, Chewe ;
Phelps, B. Ryan ;
McClure, Craig ;
Mofenson, Lynne M. ;
Stringer, Jeffrey S. A. .
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2012, 60 :S78-S87
[10]   Early infant HIV-1 diagnosis programs in resource-limited settings: opportunities for improved outcomes and more cost-effective interventions [J].
Ciaranello, Andrea L. ;
Park, Ji-Eun ;
Ramirez-Avila, Lynn ;
Freedberg, Kenneth A. ;
Walensky, Rochelle P. ;
Leroy, Valeriane .
BMC MEDICINE, 2011, 9