Bioinorganics and biomaterials: Bone repair

被引:337
作者
Habibovic, P. [2 ]
Barralet, J. E. [1 ]
机构
[1] McGill Univ, Fac Dent, Montreal, PQ H3A 2B2, Canada
[2] Univ Twente, MIRA Inst Biomed Technol & Tech Med, Dept Tissue Regenerat, NL-7523 NB Enschede, Netherlands
关键词
Bone; Bioinorganic; Bioceramic; Calcium; Phosphate; BETA-TRICALCIUM PHOSPHATE; INHIBITS OSTEOGENIC DIFFERENTIATION; CALCIUM-PHOSPHATE; ALKALINE-PHOSPHATASE; IN-VIVO; STRONTIUM RANELATE; SUBSTITUTED HYDROXYAPATITE; INORGANIC-PHOSPHATE; OSTEOBLAST DIFFERENTIATION; BIOMECHANICAL PROPERTIES;
D O I
10.1016/j.actbio.2011.03.027
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
The field of bioinorganics is well established in the development of a variety of therapies. However, their application to bone regeneration, specifically by way of localized delivery from functional implants, is in its infancy and is the topic of this review. The toxicity of inorganics is species, dose and duration specific. Little is known about how inorganic ions are effective therapeutically since their use is often the result of serendipity, observations from nutritional deficiency or excess and genetic disorders. Many researchers point to early work demonstrating a role for their element of interest as a micronutrient critical to or able to alter bone growth, often during skeletal development, as a basis for localized delivery. While one can appreciate how a deficiency can cause disruption of healing, it is difficult to explain how a locally delivered excess in a preclinical model or patient, which is presumably of normal nutritional status, can evoke more bone or faster healing. The review illustrates that inorganics can positively affect bone healing but various factors make literature comparisons difficult. Bioinorganics have the potential to have just as big an impact on bone regeneration as recombinant proteins without some of the safety concerns and high costs. (C) 2011 Published by Elsevier Ltd. on behalf of Acta Materialia Inc.
引用
收藏
页码:3013 / 3026
页数:14
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