Circulating lymphocyte and T memory subsets in glucocorticosteroid versus IVIG treated patients with CIDP

被引：19

作者：

Klehmet, Juliane ^{[1
]}

Staudt, Max ^{[1
]}

Ulm, Lena ^{[1
]}

Unterwalder, Nadine ^{[3
]}

Meisel, Andreas ^{[1
]}

Meisel, Christian ^{[2
,3
]}

机构：

[1] Charite, Dept Neurol, D-13353 Berlin, Germany

[2] Charite, Dept Med Immunol, D-13353 Berlin, Germany

[3] Labor Berlin Charite Vivantes, Dept Immunol, Berlin, Germany

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2015年 / 283卷

关键词：

CIDP; Glucocorticosteroids; IVIG; NK cells; T memory subsets; INFLAMMATORY DEMYELINATING POLYRADICULONEUROPATHY; GUILLAIN-BARRE-SYNDROME; REMITTING MULTIPLE-SCLEROSIS; NATURAL-KILLER-CELLS; PERIPHERAL-BLOOD; CONTROLLED-TRIAL; NK CELLS; INFECTION; METHYLPREDNISOLONE; POLYNEUROPATHY;

D O I：

10.1016/j.jneuroim.2015.03.023

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The present study compared lymphocyte and T memory subsets in currently untreated patients with chronic inflammatory demyelinating polyneuropathy (CIDP) to glucocorticosteroid (GS) and intravenous immunoglobulin (IVIG) treated patients. Peripheral blood from 48 CIDP patients (21 untreated who were either treatment naive or without treatment during the last 3 months, 17 IVIG and 10 GS treatment) and from 12 age-matched controls was evaluated using flow cytometric analysis. Our data demonstrate that long-term GS treatment is associated with reduced frequencies of total CD4 + T cells, CD4 + memory subsets and NK cells while long-term IVIG treatment is associated with alterations of the CD8 + memory compartment. Reduction of CD4 + naive T cell counts may explain the observation that GS treatment induces prolonged clinical remission compared to IVIG treatment. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：17 / 22

页数：6

共 43 条

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