14-3-3 protein in the CSF as prognostic marker in early multiple sclerosis

被引：60
作者：
Martínez-Yélamos, A
Saiz, A
Sanchez-Valle, R
Casado, V
Ramón, JM
Graus, F
Arbizu, T
机构：
[1] Ciutat Sanitaria Univ, Bellvitge Hosp, Serv Neurol, Lhospitalet De Llobregat, Spain
[2] Univ Barcelona, Hosp Clin Barcelona, Serv Neurol, E-08007 Barcelona, Spain
[3] Univ Barcelona, Hosp Clin Barcelona, Inst IDIBAPS, E-08007 Barcelona, Spain
来源：
NEUROLOGY | 2001年 / 57卷 / 04期
关键词：
D O I：
10.1212/WNL.57.4.722
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Axonal damage probably occurs early in the evolution of MS. Five of 38 (13%) patients had a positive assay for the neuronal 14-3-3 protein in the CSF obtained at the first clinically isolated syndrome suggestive of MS. A positive 14-3-3 assay was the only independent predictor for a shorter time to conversion to clinical definite MS (risk ratio 4.1; 95%, CI 1.1 to 15) and to reach an Expanded Disability Status Scale (EDSS) greater than or equal to 2 at the end of follow-up (odds ratio 14.8; 95% CI 2.86 to 76.8). The detection of the 14-3-3 protein in the CSF at the first neurologic event suggestive of MS may be a useful predictor of short-term evolution.
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收藏
页码：722 / 724
页数：3
相关论文
共 11 条
[1]   Detection of ventricular enlargement in patients at the earliest clinical stage of MS [J].
Brex, PA ;
Jenkins, R ;
Fox, NC ;
Crum, WR ;
O'Riordan, JI ;
Plant, GT ;
Miller, DH .
NEUROLOGY, 2000, 54 (08) :1689-1691
[2]  
Comi G, 2000, NEUROLOGY, V54, pA85
[3]  
Giovannoni G, 1998, MULT SCLER, V4, P138, DOI 10.1177/135245859800400310
[4]   14-3-3 protein in the cerebrospinal fluid of patients with acute transverse myelitis [J].
Irani, DN ;
Kerr, DA .
LANCET, 2000, 355 (9207) :901-901
[5]   Intramuscular interferon beta-1a therapy initiated during a first demyelinating event in multiple sclerosis. [J].
Jacobs, LD ;
Beck, RW ;
Simon, JH ;
Kinkel, RP ;
Brownscheidle, CM ;
Murray, TJ ;
Simonian, NA ;
Slasor, PJ ;
Sandrock, AW .
NEW ENGLAND JOURNAL OF MEDICINE, 2000, 343 (13) :898-904
[6]  
Saiz A, 1999, ANN NEUROL, V46, P774, DOI 10.1002/1531-8249(199911)46:5<774::AID-ANA14>3.0.CO
[7]  
2-N
[8]   The 14-3-3 protein detectable in the cerebrospinal fluid of patients with prion-unrelated neurological diseases is expressed constitutively in neurons and glial cells in culture [J].
Satoh, J ;
Kurohara, K ;
Yukitake, M ;
Kuroda, Y .
EUROPEAN NEUROLOGY, 1999, 41 (04) :216-225
[9]   Short-term prognosis in early relapsing-remitting multiple sclerosis [J].
Scott, TF ;
Schramke, CJ ;
Novero, J ;
Chieffe, C .
NEUROLOGY, 2000, 55 (05) :689-693
[10]   Optic neuritis -: Prognosis for multiple sclerosis from MRI, CSF, and HLA findings [J].
Söderström, M ;
Ya-Ping, J ;
Hillert, J ;
Link, H .
NEUROLOGY, 1998, 50 (03) :708-714
12