Excessive daytime sleepiness in a patient with coexisting myotonic dystrophy type 1, myasthenia gravis and Graves' disease

被引：4

作者：

Kapica-Topczewska, Katarzyna ^{[1
]}

Pogorzelski, Robert ^{[1
]}

Tarasiuk, Joanna ^{[1
]}

Drozdowski, Wieslaw ^{[1
]}

Lewczuk, Piotr ^{[2
,3
]}

Kulakowska, Alina ^{[1
]}

机构：

[1] Med Univ Bialystok, Dept Neurol, Ul Sklodowskiej 24 A, PL-15276 Bialystok, Poland

[2] Univ Klinikum Erlangen, Dept Psychiat & Psychotherapy, Erlangen, Germany

[3] Friedrich August Univ Erlangen Nurnberg, Erlangen, Germany

来源：

NEUROLOGIA I NEUROCHIRURGIA POLSKA | 2017年 / 51卷 / 02期

关键词：

Myotonic dystrophy; Myasthenia gravis; Graves' disease; Hypocretin; THYMOMA;

D O I：

10.1016/j.pjnns.2017.01.007

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A 41-year-old female with history of Graves' disease, bilateral cataract, paroxysmal atrial fibrillation was admitted because of muscle weakness, daytime sleepiness, fatigability, drowsiness, bilateral eyelid ptosis, descending of head and lower jaw. On neurological examination the patient was presented with muscle weakness, muscle atrophy (in face and sternocleidomastoid muscles), features of myotonia and apocamnosis (orbicular muscles). Electromyography revealed myopathic changes, myotonic and pseudomyotonic discharges, positive repetitive nerve stimulation test in proximal muscles. Myotonic dystrophy (MD) diagnosis was confirmed by genetic testing and myasthenia gravis (MG) by a positive titer of cholinergic receptor autoantibodies. In the CSF concentration of hypocretin was significantly decreased. (C) 2017 Polish Neurological Society. Published by Elsevier Sp. z o.o. All rights reserved.

引用

页码：190 / 193

页数：4

共 17 条

[1]

Abrams GM, 2000, MERRITTS NEUROLOGY, P849

[2]

Avaria MD, 2007, PEDIATR NEUROL, V36, P421, DOI 10.1016/j.pediatrneurol.2007.01.014

[3] The hypocretin neurotransmission system in myotonic dystrophy type 1 [J].

Ciafaloni, E. ;

Mignot, E. ;

Sansone, V. ;

Hilbert, J. E. ;

Lin, L. ;

Lin, X. ;

Liu, L. C. ;

Pigeon, W. R. ;

Perlis, M. L. ;

Thornton, C. A. .

NEUROLOGY, 2008, 70 (03) :226-230

[4] Myasthenia gravis and thymoma coexisting with myotonic dystrophy type 1 [J].

Ekmekci, Ozgul ;

Karasoy, Hatice ;

Bademkiran, Fikret ;

Akkus, Dilek Evyapan ;

Yuceyar, Nur .

NEUROMUSCULAR DISORDERS, 2014, 24 (01) :40-42

[5] Sleep in Neuromuscular Diseases [J].

Fermin, Anna Monica ;

Afzal, Umair ;

Culebras, Antonio .

SLEEP MEDICINE CLINICS, 2016, 11 (01) :53-+

[6] Myotonic dystrophy type 1 coexisting with myasthenia gravis and thymoma [J].

Feyma, Timothy ;

Carter, Gregory T. ;

Weiss, Michael D. .

MUSCLE & NERVE, 2008, 38 (01) :916-920

[7] THYROID-FUNCTION IN PATIENTS WITH MYOTONIC-DYSTROPHY [J].

FUKAZAWA, H ;

SAKURADA, T ;

YOSHIDA, K ;

KAISE, N ;

KAISE, K ;

NOMURA, T ;

YAMAMOTO, M ;

SAITO, S ;

TAKASE, S ;

YOSHINAGA, K .

CLINICAL ENDOCRINOLOGY, 1990, 32 (04) :485-490

[8] HYPERSOMNIA ASSOCIATED WITH ALVEOLAR HYPOVENTILATION IN MYOTONIC-DYSTROPHY [J].

HANSOTIA, P ;

FRENS, D .

NEUROLOGY, 1981, 31 (10) :1336-1337

[9]

HARLEY HG, 1993, AM J HUM GENET, V52, P1164

[10] A NEW METHOD FOR MEASURING DAYTIME SLEEPINESS - THE EPWORTH SLEEPINESS SCALE [J].

JOHNS, MW .

SLEEP, 1991, 14 (06) :540-545

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