Association of PNPLA3 I148M Variant With Chronic Viral Hepatitis, Autoimmune Liver Diseases and Outcomes of Liver Transplantation

被引:3
作者
Geng, Ning [1 ]
Xin, Yong-Ning [2 ]
Xia, Harry Hua-Xiang [3 ]
Jiang, Man [2 ]
Wang, Jian [1 ]
Liu, Yang [1 ]
Chen, Li-Zhen [1 ]
Xuan, Shi-Ying [2 ]
机构
[1] Qingdao Univ, Qingdao Municipal Hosp, Coll Med, Qingdao 266071, Peoples R China
[2] Qingdao Municipal Hosp, Dept Gastroenterol, Qingdao, Peoples R China
[3] Qingdao Univ, Qingdao Municipal Hosp, Qingdao 266071, Peoples R China
基金
中国国家自然科学基金;
关键词
PNPLA3; Polymorphism; Hepatitis B; Chronic; Hepatitis C; Autoimmune Hepatitis; Liver Transplantation; HEPATOCELLULAR-CARCINOMA; C-VIRUS; FIBROSIS PROGRESSION; INSULIN-RESISTANCE; METABOLIC SYNDROME; GENETIC-VARIANTS; RISK-FACTOR; STEATOSIS; GENOTYPE; HCV;
D O I
10.5812/hepatmon.15(4)2015.26459
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Context: The PNPLA3 I148M variant has been recognized as a genetic determinant of liver fat content and a genetic risk factor of liver damage progression associated with steatohepatitis. The I148M variant is associated with many chronic liver diseases. However, its potential association with inflammatory and autoimmune liver diseases has not been established. Evidence Acquisition: We systemically reviewed the potential associations of I148M variant with chronic viral hepatitis, autoimmune liver diseases and the outcome of liver transplantation, explored the underlying molecular mechanisms and tried to translate them into more individualized decision-making and personalized medicine. Results: There were associations between I148M variant and chronic viral hepatitis and autoimmune liver diseases and differential associations of I148M variant in donors and recipients with post-liver transplant outcomes. I148M variant may activate the development of steatosis caused by host metabolic disorders in chronic viral hepatitis, but few researches were found to illustrate the mechanisms in autoimmune liver diseases. The peripherally mediated mechanism (via extrahepatic adipose tissue) may play a principal role in triglyceride accumulation regardless of adiponutrin activity in the graft liver. Conclusions: Evidences have shown the associations between I148M variant and mentioned diseases. I148M variant induced steatosis may be involved in the mechanism of chronic viral hepatitis and genetic considered personalized therapies, especially for PSC male patients. It is also crucial to pay attention to this parameter in donor selection and prognosis estimation in liver transplantation.
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页数:6
相关论文
共 64 条
[1]   Understanding the Role of PNPLA3 Genetic Variants in Patients with Chronic Hepatitis C Infection [J].
Aghemo, Alessio .
DIGESTIVE DISEASES AND SCIENCES, 2012, 57 (08) :1977-1979
[2]   Liver Transplantation and Hepatitis C [J].
Akamatsu, Nobuhisa ;
Sugawara, Yasuhiko .
INTERNATIONAL JOURNAL OF HEPATOLOGY, 2012, 2012
[3]   Development of Mouse Hepatocyte Lines Permissive for Hepatitis C Virus (HCV) [J].
Aly, Hussein Hassan ;
Oshiumi, Hiroyuki ;
Shime, Hiroaki ;
Matsumoto, Misako ;
Wakita, Taka ;
Shimotohno, Kunitada ;
Seya, Tsukasa .
PLOS ONE, 2011, 6 (06)
[4]  
[Anonymous], HEPAT MON
[5]   HCV and the hepatic lipid pathway as a potential treatment target [J].
Bassendine, Margaret F. ;
Sheridan, David A. ;
Felmlee, Daniel J. ;
Bridge, Simon H. ;
Toms, Geoffrey L. ;
Neely, R. Dermot G. .
JOURNAL OF HEPATOLOGY, 2011, 55 (06) :1428-1440
[6]  
Bugianesi E, 2012, J HEPATOL, V56, pS56, DOI 10.1016/S0168-8278(12)60007-5
[7]   Viral genotype-specific role of PNPLA3, PPARG, MTTP, and IL28B in hepatitis C virus-associated steatosis [J].
Cai, Tao ;
Dufour, Jean-Francois ;
Muellhaupt, Beat ;
Gerlach, Tilman ;
Heim, Markus ;
Moradpour, Darius ;
Cerny, Andreas ;
Malinverni, Raffaele ;
Kaddai, Vincent ;
Bochud, Murielle ;
Negro, Francesco ;
Bochud, Pierre-Yves .
JOURNAL OF HEPATOLOGY, 2011, 55 (03) :529-535
[8]   PNPLA3/adiponutrin functions in lipid droplet formation [J].
Chamoun, Zeina ;
Vacca, Fabrizio ;
Parton, Robert G. ;
Gruenberg, Jean .
BIOLOGY OF THE CELL, 2013, 105 (05) :219-233
[9]   The Association of Genetic Variants with Hepatic Steatosis in Patients with Genotype 1 Chronic Hepatitis C Infection [J].
Clark, Paul J. ;
Thompson, Alexander J. ;
Zhu, Qianqian ;
Vock, David M. ;
Zhu, Mingfu ;
Patel, Keyur ;
Harrison, Stephen A. ;
Naggie, Susanna ;
Ge, Dongliang ;
Tillmann, Hans L. ;
Urban, Thomas J. ;
Shianna, Kevin ;
Fellay, Jacques ;
Goodman, Zachary ;
Noviello, Stephanie ;
Pedicone, Lisa D. ;
Afdhal, Nezam ;
Sulkowski, Mark ;
Albrecht, Janice K. ;
Goldstein, David B. ;
McHutchison, John G. ;
Muir, Andrew J. .
DIGESTIVE DISEASES AND SCIENCES, 2012, 57 (08) :2213-2221
[10]   Patatin-Like Phospholipase Domain Containing 3 Sequence Variant and Hepatocellular Carcinoma [J].
Corradini, Stefano Ginanni ;
Burza, Maria Antonella ;
Molinaro, Antonio ;
Romeo, Stefano .
HEPATOLOGY, 2011, 53 (05) :1776-1776