A new C(1)-auxiliary for anomeric stereocontrol in the synthesis of α-sialyl glycosides

被引：48

作者：

Haberman, JM ^{[1
]}

Gin, DY ^{[1
]}

机构：

[1] Univ Illinois, Dept Chem, Urbana, IL 61801 USA

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 11期

关键词：

D O I：

10.1021/ol015854i

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The installation of the novel N,N-dimethylglycolamide ester auxiliary onto the C(1)-position of protected neuraminic acid donors allows for the exploitation of C(1)-neighboring group participation to generate sialoside conjugates with good to excellent or-selectivity under a variety of sialylation protocols, including those that would otherwise lead to nonselective or beta -selective sialoside products.

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页码：1665 / 1668

页数：4

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