Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview

被引：36

作者：

Delaby, Constance ^{[1
,4
]}

Teunissen, Charlotte E. ^{[2
]}

Blennow, Kaj ^{[3
]}

Alcolea, Daniel ^{[4
]}

Arisi, Ivan ^{[5
]}

Amar, Elodie Bouaziz ^{[6
]}

Beaume, Anne ^{[7
]}

Bedel, Aurelie ^{[8
]}

Bellomo, Giovanni ^{[9
]}

Bigot-Corbel, Edith ^{[10
]}

Bjerke, Maria ^{[11
,12
,24
]}

Blanc-Quintin, Marie-Celine ^{[13
]}

Boada, Merce ^{[14
,15
,16
,73
]}

Bousiges, Olivier ^{[17
,18
,19
]}

Chapman, Miles D. ^{[20
]}

DeMarco, Mari L. ^{[21
,22
]}

D'Onofrio, Mara ^{[5
]}

Dumurgier, Julien ^{[6
]}

Dufour-Rainfray, Diane ^{[23
]}

Engelborghs, Sebastiaan ^{[24
,25
,26
]}

Esselmann, Hermann ^{[27
]}

Fogli, Anne ^{[28
]}

Gabelle, Audrey ^{[1
]}

Galloni, Elisabetta ^{[29
]}

Gondolf, Clementine ^{[30
]}

Grandhomme, Frederique ^{[30
]}

Grau-Rivera, Oriol ^{[31
,32
,33
,34
]}

Hart, Melanie ^{[20
]}

Ikeuchi, Takeshi ^{[35
]}

Jeromin, Andreas ^{[36
]}

Kasuga, Kensaku ^{[35
]}

Keshavan, Ashvini ^{[37
]}

Khalil, Michael ^{[38
]}

Koertvelyessy, Peter ^{[39
,40
,41
]}

Kulczynska-Przybik, Agnieszka ^{[42
]}

Laplanche, Jean-Louis ^{[6
]}

Lewczuk, Piotr ^{[42
,43
,44
]}

Li, Qiao-Xin ^{[45
,46
]}

Lleo, Alberto ^{[4
]}

Malaplate, Catherine ^{[47
]}

Marquie, Marta ^{[14
,15
,16
,73
]}

Masters, Colin L. ^{[45
,46
]}

Mroczko, Barbara ^{[42
]}

Nogueira, Leonor ^{[48
]}

Orellana, Adelina ^{[14
,15
,16
,73
]}

Otto, Markus ^{[49
,50
]}

Oudart, Jean-Baptiste ^{[51
]}

Paquet, Claire ^{[6
]}

Paoletti, Federico Paolini ^{[9
]}

Parnetti, Lucilla ^{[9
]}

机构：

[1] Univ Montpellier, INSERM, CHU Montpellier, LBPC PPC, Montpellier, France

[2] Vrije Univ Amsterdam, Dept Clin Chem, Neurochem Lab, Amsterdam UMC,Amsterdam Neurosci, Amsterdam, Netherlands

[3] Univ Gothenburg, Inst Neurosci & Physiol, Sahlgrenska Acad, Gothenburg, Sweden

[4] Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Biomed Res Inst St Pau, Barcelona, Spain

[5] European Brain Res Inst EBRI Rita Levi Montalcini, Rome, Italy

[6] Univ Paris, GHU APHP Nord Lariboisiere Fernand Widal Hosp, Cognit Neurol Ctr, Paris, France

[7] CHU Poitiers, Poitiers, France

[8] CHU Bordeaux, Bordeaux, France

[9] Univ Perugia, Dept Med & Surg, Sect Neurol, Lab Clin Neurochem, Perugia, Italy

[10] CHU Nantes, Lab Biochim, Hop G&R Laennec, Nantes, France

[11] Vrije Univ Brussel, Ctr Neurosci, Brussels, Belgium

[12] Univ Ziekenhuis Brussel, Dept Clin Biol, Clin Neurochem Lab, Brussels, Belgium

[13] APHP Ctr Univ Paris, Cochin Hosp, Paris, France

[14] Inst Catala Neurociencies Aplicades, Res Ctr, Fundacio ACE, Barcelona, Spain

[15] Inst Catala Neurociencies Aplicades, Memory Clin, Fundacio ACE, Barcelona, Spain

[16] Univ Int Catalunya UIC, Barcelona, Spain

[17] Hop Univ Strasbourg, Lab Biochim & Biol Mol, Strasbourg, France

[18] Hop Univ Strasbourg, CNRS, ICube Lab UMR 7357, Strasbourg, France

[19] Hop Univ Strasbourg, Team IMIS, FMTS Federat Med Translat Strasbourg, Strasbourg, France

[20] UCL Queen Sq, Dept Neuroimmunol, Natl Hosp Neurol & Neurosurg, London, England

[21] St Pauls Hosp, Dept Pathol & Lab Med, Providence Hlth Care, Vancouver, BC, Canada

[22] Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC, Canada

[23] CHU Tours, UMR 1253 iBrain, Tours, France

[24] Univ Antwerp, Inst Born Bunge, Dept Biomed Sci, Antwerp, Belgium

[25] Vrije Univ Brussel, Univ Ziekenhuis Brussel, Ctr Neurosci, Brussels, Belgium

[26] Vrije Univ Brussel, Univ Ziekenhuis Brussel, Dept Neurol, Brussels, Belgium

[27] Univ Med Ctr Goettingen UMG, Dept Psychiat & Psychotherapy, Gottingen, Germany

[28] CHU Clermont Ferrand, Clermont Ferrand, France

[29] Dipartimento Neurosci, Div Neurol, Vicenza, Italy

[30] CHU Cote Nacre Caen, Caen, France

[31] Pasqual Maragall Fdn, Barcelonasseta Brain Res Ctr BBRC, Barcelona, Spain

[32] Hosp del Mar, Serv Neurol, Unitat Deteriorament Cognitiu & Transtorns Movime, Barcelona, Spain

[33] IMIM Hosp del Mar Med Res Inst, Barcelona, Spain

[34] Ctr Invest Biomed Red Fragilidad & Envejecimiento, Madrid, Spain

[35] Niigata Univ, Ctr Bioresources, Brain Res Inst, Dept Mol Genet, Niigata, Japan

[36] Cohen Vet Biosci, Cambridge, MA USA

[37] UCL Queen Sq Inst Neurol, Dementia Res Ctr, London, England

[38] Med Univ Graz, Graz, Austria

[39] Free Univ Berlin, Berlin, Germany

[40] Humboldt Univ, Dept Neurol, German Ctr Neurodegenerat Dis, Magdeburg, Germany

[41] Charite Univ Med Berlin, Berlin, Germany

[42] Med Univ Bialystok, Dept Neurodegenerat Diagnost, Bialystok, Poland

[43] Univ Klinikum Erlangen, Lab Clin Neurochem & Neurochem Dementia Diagnost, Erlangen, Germany

[44] Friedrich Alexander Univ Erlangen Nurnberg, Erlangen, Germany

[45] Florey Inst, Melbourne, Vic, Australia

[46] Univ Melbourne, Melbourne, Vic, Australia

[47] Univ Lorraine, Lab Biochim Biol Mol & Nutr, CHRU Nancy, Nancy, France

[48] CHU PURPAN, Lab Biol Cellulaire & Cytol, Toulouse, France

[49] Univ Ulm, Dept Neurol, Ulm, Germany

[50] Univ Ulm, CSF Lab, Ulm, Germany

来源：

ALZHEIMERS & DEMENTIA | 2022年 / 18卷 / 10期

基金：

欧洲研究理事会; 欧盟地平线“2020”; 荷兰研究理事会; 美国国家卫生研究院; 英国医学研究理事会; 瑞典研究理事会;

关键词：

Alzheimer's disease; cerebrospinal fluid biomarkers; clinical report; consensus approach; harmonization; RECOMMENDATIONS; DIAGNOSIS; CRITERIA;

D O I：

10.1002/alz.12545

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: The current practice of quantifying cerebrospinal fluid (CSF) biomarkers as an aid in the diagnosis of Alzheimer's disease (AD) varies from center to center. For a same biochemical profile, interpretation and reporting of resultsmay differ, which can lead tomisunderstandings and raises questions about the commutability of tests. Methods: We obtained a description of (pre-)analytical protocols and sample reports from 40 centers worldwide. A consensus approach allowed us to propose harmonized comments corresponding to the different CSF biomarker profiles observed in patients. Results: The (pre-)analytical procedures were similar between centers. There was considerable heterogeneity in cutoff definitions and report comments. We therefore identified and selected by consensus the most accurate and informative comments regarding the interpretation of CSF biomarkers in the context of AD diagnosis. Discussion: This is the first time that harmonized reports are proposed across worldwide specialized laboratories involved in the biochemical diagnosis of AD.

引用

页码：1868 / 1879

页数：12

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