The regulation of immune tolerance by FOXP3

被引：419

作者：

Lu, Ling ^{[1
]}

Barbi, Joseph ^{[2
]}

Pan, Fan ^{[3
]}

机构：

[1] Nanjing Med Univ, Affiliated Hosp 1, Liver Transplantat Ctr, 300 Guangzhou Rd, Nanjing 210029, Jiangsu, Peoples R China

[2] Roswell Pk Canc Inst, Dept Immunol, Elm & Carlton St, Buffalo, NY 14263 USA

[3] Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr, Dept Oncol,Immunol & Hematopoiesis Div, 401 North Broadway, Baltimore, MD 21287 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2017年 / 17卷 / 11期

基金：

美国国家卫生研究院;

关键词：

TRANSCRIPTION FACTOR FOXP3; T-CELL FUNCTION; TGF-BETA; B-CELLS; CUTTING EDGE; HISTONE ACETYLTRANSFERASE; SUPPRESSIVE ACTIVITY; PROMOTER OCCUPANCY; SPLICE VARIANTS; TARGET GENES;

D O I：

10.1038/nri.2017.75

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The proper restraint of the destructive potential of the immune system is essential for maintaining health. Regulatory T (T-reg) cells ensure immune homeostasis through their defining ability to suppress the activation and function of other leukocytes. The expression of the transcription factor forkhead box protein P3 (FOXP3) is a well-recognized characteristic of Treg cells, and FOXP3 is centrally involved in the establishment and maintenance of the Treg cell phenotype. In this Review, we summarize how the expression and activity of FOXP3 are regulated across multiple layers by diverse factors. The therapeutic implications of these topics for cancer and autoimmunity are also discussed.

引用

页码：703 / 717

页数：15

共 50 条

[1] The regulation of immune tolerance by FOXP3
Ling Lu
Joseph Barbi
Fan Pan
Nature Reviews Immunology, 2017, 17 : 703 - 717
[2] Zebrafish FOXP3 is required for the maintenance of immune tolerance
Sugimoto, Kotaro
Hui, Subhra P.
Sheng, Delicia Z.
Nakayama, Maki
Kikuchi, Kazu
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2017, 73 : 156 - 162
[3] You, me and Foxp3: immune regulation for two
Tsun, Andy
Li, Yang Yang
Li, Bin
IMMUNOTHERAPY, 2011, 3 (10) : 1139 - 1142
[4] FOXP3, the Transcription Factor at the Heart of the Rebirth of Immune Tolerance
Bluestone, Jeffrey A.
JOURNAL OF IMMUNOLOGY, 2017, 198 (03): : 979 - 980
[5] Foxp3 and dominant tolerance
Rudensky, A
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2005, 360 (1461) : 1645 - 1646
[6] Foxp3: Shades of Tolerance
Chatila, Talal A.
Williams, Calvin B.
IMMUNITY, 2012, 36 (05) : 693 - 694
[7] Epigenetic Regulation of Foxp3 Expression in Tolerance and Inflammation.
Lal, Girdhari
Zhang, Nan
van der Touw, William
Ding, Yaozhong
Bromberg, Jonathan S.
AMERICAN JOURNAL OF TRANSPLANTATION, 2009, 9 : 242 - 242
[8] IMMUNE REGULATION Macrophages join the FOXP3 suppressor gang
Leavy, Olive
NATURE REVIEWS IMMUNOLOGY, 2011, 11 (07) : 438 - 438
[9] Immune regulation within the graft is mediated by FLIP and Foxp3
Baan, CC
van der Mast, BJ
Dijke, E
de Groot-Kruseman, HA
Korevaar, SS
Maat, LP
Balk, AH
Weimar, W
AMERICAN JOURNAL OF TRANSPLANTATION, 2004, 4 : 513 - 513
[10] Exon 2 of Foxp3 contributes to the peripheral tolerance of the immune system
Du, Jianguang
Wang, Qun
Wang, Lina
Zhou, Baohua
JOURNAL OF IMMUNOLOGY, 2016, 196

← 1 2 3 4 5 →