The role of biofilms in onychomycosis

被引：70

作者：

Gupta, Aditya K. ^{[1
,2
]}

Daigle, Deanne ^{[2
]}

Carviel, Jessie L. ^{[2
]}

机构：

[1] Univ Toronto, Dept Med, Toronto, ON M5S 1A1, Canada

[2] Mediprobe Res Inc, 645 Windermere Rd, London, ON N5X 2P1, Canada

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 2016年 / 74卷 / 06期

关键词：

antifungal; biofilm; dermatophyte fungi; extracellular matrix; nail; onychomycosis; CANDIDA-ALBICANS BIOFILMS; AMOROLFINE NAIL LACQUER; STAPHYLOCOCCUS-AUREUS; ASPERGILLUS-FUMIGATUS; TRICHOPHYTON-RUBRUM; ANTIFUNGAL SUSCEPTIBILITY; CRYPTOCOCCUS-NEOFORMANS; ORAL TERBINAFINE; GENE-EXPRESSION; FUNGAL BIOFILMS;

D O I：

10.1016/j.jaad.2016.01.008

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Onychomycosis is a fungal infection of nails primarily caused by dermatophyte fungi. Fungi are traditionally understood as existing in the environment as planktonic organisms; however, recent advancements in microbiology suggest that fungi form biofilms-complex sessile microbial communities irreversibly attached to epithelial surfaces by means of an extracellular matrix. The extracellular matrix also acts as a protective barrier to the organisms within the biofilm. The biofilm is surprisingly resistant to injury and may act as a persistent source of infection possibly accounting for antifungal resistance in onychomycosis.

引用

页码：1241 / 1246

页数：6

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