Long noncoding RNAs (lncRNAs) in pancreatic cancer progression

被引：53

作者：

Ashrafizaden, Milad ^{[1
,7
]}

Rabiee, Navid ^{[2
,3
]}

Kumar, Alan Prem ^{[4
,5
]}

Sethi, Gautam ^{[4
,5
]}

Zarrabi, Ali ^{[6
,7
]}

Wang, Yuzhuo ^{[7
,8
]}

机构：

[1] Sabanci Univ, Fac Engn & Nat Sci, Univ Caddesi 27, TR-34956 Tuzla, Istanbul, Turkey

[2] Pohang Univ Sci & Technol POSTECH, Dept Mat Sci & Engn, 77 Cheongam Ro, Pohang 37673, Gyeongbuk, South Korea

[3] Macquarie Univ, Sch Engn, Sydney, NSW 2109, Australia

[4] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Pharmacol, Singapore 117599, Singapore

[5] Natl Univ Singapore, NUS Ctr Canc Res N2CR, Yong Loo Lin Sch Med, Singapore, Singapore

[6] Istinye Univ, Fac Engn & Nat Sci, Dept Biomed Engn, TR-34396 Istanbul, Turkey

[7] Dept Urol Sci, Vancouver, BC V6H3Z6, Canada

[8] Univ British Columbia, Vancouver Prostate Ctr, Vancouver, BC V6H3Z6, Canada

来源：

DRUG DISCOVERY TODAY | 2022年 / 27卷 / 08期

基金：

加拿大健康研究院;

关键词：

lncRNA; Pancreatic cancer; miRNA; Chemoresistance; Cancer therapy; Invasion; EPITHELIAL-MESENCHYMAL TRANSITION; PROMOTES GEMCITABINE RESISTANCE; STEM-LIKE CELLS; COLORECTAL-CANCER; SIGNALING PATHWAY; GASTRIC-CANCER; PROLIFERATION; METASTASIS; EXPRESSION; TUMORIGENESIS;

D O I：

10.1016/j.drudis.2022.05.012

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Long noncoding RNAs (lncRNAs) are RNA molecules involved in gene regulation at transcriptional, post-transcriptional, and epigenetic levels. LncRNAs participate in regulating apoptosis and autophagy in pancreatic cancer (PCa) and can promote and/or decrease the proliferation rate of tumor cells. The metastasis of PCa cells is tightly regulated by lncRNAs and they can affect the mechanism of epithelial-mesenchymal transition (EMT) to modulate metastasis. The drug resistance of PCa cells, especially to gemcitabine, can be affected by lncRNAs. In addition, lncRNAs enriched in exosomes can be transferred among tumor cells to regulate their proliferation and metastasis. Antitumor compounds, such as curcumin and ginsenosides, can regulate lncRNA expression in PCa therapy. As we discuss here, the expression level of lncRNAs can be considered as both a diagnostic and prognostic tool in patients with PCa.

引用

页码：2181 / 2198

页数：18

共 201 条

[1] Curcumin and its derivatives in cancer therapy: Potentiating antitumor activity of cisplatin and reducing side effects [J].