Microseizures and the spatiotemporal scales of human partial epilepsy

被引：237

作者：

Stead, Matt ^{[1
]}

Bower, Mark ^{[1
]}

Brinkmann, Benjamin H. ^{[1
]}

Lee, Kendall ^{[2
]}

Marsh, W. Richard ^{[2
]}

Meyer, Fredric B. ^{[2
]}

Litt, Brian ^{[3
,4
]}

Van Gompel, Jamie ^{[2
]}

Worrell, Greg A. ^{[1
]}

机构：

[1] Mayo Clin, Dept Neurol, Div Epilepsy & Electroencephalog, Mayo Syst Electrophysiol Lab, Rochester, MN 55905 USA

[2] Mayo Clin, Dept Neurosurg, Div Epilepsy & Electroencephalog, Mayo Syst Electrophysiol Lab, Rochester, MN 55905 USA

[3] Univ Penn, Dept Neurol, Philadelphia, PA 19104 USA

[4] Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA

来源：

BRAIN | 2010年 / 133卷

基金：

美国国家卫生研究院;

关键词：

epilepsy; seizure; intracranial EEG; microseizure; microcircuit; seizure generation; ictogenesis; epileptogenesis; HIGH-FREQUENCY OSCILLATIONS; NEOCORTICAL EPILEPSY; SEIZURE PREDICTION; TEMPORAL-LOBE; HIPPOCAMPAL-NEURONS; CORTEX; RECORDINGS; ONSET; ORGANIZATION; STIMULATION;

D O I：

10.1093/brain/awq190

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Focal seizures appear to start abruptly and unpredictably when recorded from volumes of brain probed by clinical intracranial electroencephalograms. To investigate the spatiotemporal scale of focal epilepsy, wide-bandwidth electrophysiological recordings were obtained using clinical macro- and research microelectrodes in patients with epilepsy and control subjects with intractable facial pain. Seizure-like events not detectable on clinical macroelectrodes were observed on isolated microelectrodes. These 'microseizures' were sparsely distributed, more frequent in brain regions that generated seizures, and sporadically evolved into large-scale clinical seizures. Rare microseizures observed in control patients suggest that this phenomenon is ubiquitous, but their density distinguishes normal from epileptic brain. Epileptogenesis may involve the creation of these topographically fractured microdomains and ictogenesis (seizure generation), the dynamics of their interaction and spread.

引用

页码：2789 / 2797

页数：9

共 35 条

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