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Synthesis of 2,3,4-trisubstituted pyrrole derivatives via [3+2] cyclization of activated methylene isocyanides with 4-(arylidene)-2-substituted oxazol-5(4H)-ones
被引:9
作者:
Zhang, Jing
[1
,2
]
Liu, Man
[2
]
Li, Chao
[2
]
Xu, Yan-Jun
[1
]
Dong, Lin
[2
]
机构:
[1] Sichuan Normal Univ, Coll Chem & Mat Sci, Chengdu 610066, Sichuan, Peoples R China
[2] Sichuan Univ, West China Sch Pharm, Educ Minist, Key Lab Drug Targeting & Drug Delivery Syst, Chengdu 610041, Peoples R China
关键词:
ALPHA-ACIDIC ISOCYANIDES;
REGIOSELECTIVE SYNTHESIS;
1,3-DIPOLAR CYCLOADDITION;
POLYSUBSTITUTED PYRROLES;
SUBSTITUTED PYRROLES;
CONGOCIDINE;
ISOCYANOACETATES;
ANNULATION;
ALKYNES;
YLIDES;
D O I:
10.1039/c9qo01044k
中图分类号:
O62 [有机化学];
学科分类号:
070303 ;
081704 ;
摘要:
An efficient base-catalyzed [3 + 2] cyclization between isocyanides and 4-(arylidene)-2-substituted oxazol-5(4H)-ones has been successfully developed to form 2,3,4-trisubstituted and 2,2,3,4-tetrasubstituted pyrrole derivatives. This transition metal free reaction occurs at room temperature under environmentally friendly conditions, tolerating water and air.
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页码:420 / 424
页数:5
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