Synthesis of 2,3,4-trisubstituted pyrrole derivatives via [3+2] cyclization of activated methylene isocyanides with 4-(arylidene)-2-substituted oxazol-5(4H)-ones

被引：10

作者：

Zhang, Jing ^{[1
,2
]}

Liu, Man ^{[2
]}

Li, Chao ^{[2
]}

Xu, Yan-Jun ^{[1
]}

Dong, Lin ^{[2
]}

机构：

[1] Sichuan Normal Univ, Coll Chem & Mat Sci, Chengdu 610066, Sichuan, Peoples R China

[2] Sichuan Univ, West China Sch Pharm, Educ Minist, Key Lab Drug Targeting & Drug Delivery Syst, Chengdu 610041, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2020年 / 7卷 / 02期

关键词：

ALPHA-ACIDIC ISOCYANIDES; REGIOSELECTIVE SYNTHESIS; 1,3-DIPOLAR CYCLOADDITION; POLYSUBSTITUTED PYRROLES; SUBSTITUTED PYRROLES; CONGOCIDINE; ISOCYANOACETATES; ANNULATION; ALKYNES; YLIDES;

D O I：

10.1039/c9qo01044k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient base-catalyzed [3 + 2] cyclization between isocyanides and 4-(arylidene)-2-substituted oxazol-5(4H)-ones has been successfully developed to form 2,3,4-trisubstituted and 2,2,3,4-tetrasubstituted pyrrole derivatives. This transition metal free reaction occurs at room temperature under environmentally friendly conditions, tolerating water and air.

引用

页码：420 / 424

页数：5

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