Highly stereoselective and catalyst-free synthesis of annulated tetrahydropyridines by intramolecular imino-Diels-Alder reaction under microwave irradiation in water

被引:15
作者
Lezana, Nicolas [1 ]
Matus-Perez, Massiel [1 ]
Galdamez, Antonio [1 ]
Luehr, Susan [2 ]
Vilches-Herrer, Marcelo [1 ]
机构
[1] Univ Chile, Fac Sci, Dept Chem, Las Palmeras 3425, Santiago 7800024, Chile
[2] Univ Santiago Chile, Fac Chem & Biol, Dept Mat Sci, Av Libertador Bernardo OHiggins 3363, Santiago 9170022, Chile
关键词
ONE-POT; N-ARYLIMINES; 1-AZA-1,3-BUTADIENE; DERIVATIVES; ALDEHYDES; MECHANISM;
D O I
10.1039/c6gc00912c
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A microwave-assisted method for the synthesis of tetracyclic tetra-hydropyridines via an intramolecular imino-Diels-Alder reaction in water is reported. The reaction proceeds under catalyst-free conditions and shows excellent stereoselectivity.
引用
收藏
页码:3712 / 3717
页数:6
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