Increased midkine gene expression in childhood B-precursor acute lymphoblastic leukemia

被引：23

作者：

Hidaka, Hirokazu

Yagasaki, Hiroshi

Takahashi, Yoshiyuki

Hama, Asahito

Nishio, Nobuhiro

Tanaka, Makito

Yoshida, Nao

Villalobos, Itzel Bustos

Wang, Yue

Xu, YinYan

Horibe, Keizo

Chen, Sen

Kadomatsu, Kenji

Kojima, Seiji

机构：

[1] Nagoya Univ, Grad Sch Med, Dept Pediat, Showa Ku, Nagoya, Aichi 4668550, Japan

[2] Natl Hosp Org Nagoya Med Ctr, Res Ctr, Nagoya, Aichi, Japan

[3] Nagoya Univ, Grad Sch Med, Dept Biochem, Nagoya, Aichi, Japan

来源：

LEUKEMIA RESEARCH | 2007年 / 31卷 / 08期

关键词：

midkine; acute leukemia; children; prognostic factor; minimal residual disease; real-time PCR; WT1;

D O I：

10.1016/j.leukres.2006.12.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Midkine (MK) is a heparin-binding growth factor that is overexpressed in a number of solid cancers. However, expression in acute leukemia has not been clarified. We examined MK gene expression using real-time PCR in 94 children with acute leukemia. In 30 of the 41 patients with B-precursor ALL, MK gene expression was overexpressed than normal BM. MK gene was also overexpressed in more than half of patients with FAB M1 and M2 types of AML. Quantification of MK gene by real-time PCR offers particular promise as a prognostic marker and a marker for minimal residual disease in children with B-precursor ALL. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：1045 / 1051

页数：7

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