Successful Early Rituximab Treatment in a Case of Systemic Lupus Erythematosus with Potentially Fatal Diffuse Alveolar Hemorrhage

被引：14

作者：

Na, Ju Ock ^{[1
]}

Chang, Sung Hae ^{[2
]}

Seo, Ki-Hyeon ^{[1
]}

Choi, Jae Sung ^{[1
]}

Lee, Ho Sung ^{[1
]}

Lyu, Ji Won ^{[1
]}

Nah, Seoung-Su ^{[2
]}

机构：

[1] Soonchunhyang Univ, Coll Med, Dept Internal Med, Div Pulmonol, Cheonan Si 330930, Chungcheongnam, South Korea

[2] Soonchunhyang Univ, Coll Med, Dept Internal Med, Div Rheumatol, Cheonan Si 330930, Chungcheongnam, South Korea

来源：

RESPIRATION | 2015年 / 89卷 / 01期

关键词：

Systemic lupus erythematosus; Diffuse alveolar hemorrhage; Rituximab; PULMONARY HEMORRHAGE; PATIENT; MANIFESTATIONS; THERAPY; OLD;

D O I：

10.1159/000369038

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Diffuse alveolar hemorrhage (DAH) is a rare but devastating complication of systemic lupus erythematosus (SLE) with a high early mortality rate. DAH seldom occurs without active organ involvement. Recently, rituximab (RTX), a B cell-targeted therapy, has been reported to be effective for life-threatening autoimmune diseases. We describe a SLE patient who presented with acute respiratory failure due to DAH without other active organ involvement. This condition was dramatically improved with RTX without cyclophosphamide. (C) 2014 S. Karger AG, Basel

引用

收藏

页码：62 / 65

页数：4

相关论文

共 15 条

[1] Pulmonary hemorrhage in systemic lupus erythematosus [J].

Badsha, H ;

Teh, CL ;

Kong, KO ;

Lian, TY ;

Chng, HH .

SEMINARS IN ARTHRITIS AND RHEUMATISM, 2004, 33 (06) :414-421

[2] Rituximab: rescue therapy in life-threatening complications or refractory autoimmune diseases: a single center experience [J].

Braun-Moscovici, Yolanda ;

Butbul-Aviel, Yonatan ;

Guralnik, Ludmila ;

Toledano, Kochava ;

Markovits, Doron ;

Rozin, Alexander ;

Nahir, Menahem A. ;

Balbir-Gurman, Alexandra .

RHEUMATOLOGY INTERNATIONAL, 2013, 33 (06) :1495-1504

[3] Effective Treatment of Refractory Pulmonary Hemorrhage with Monoclonal Anti-CD20 Antibody (Rituximab) [J].

Fernando Pinto, Luis ;

Candia, Liliana ;

Garcia, Patricia ;

Ignacio Marin, Juan ;

Pachon, Ines ;

Espinoza, Luis R. ;

Marquez, Javier .

RESPIRATION, 2009, 78 (01) :106-109

[4] Pulmonary Manifestations of Systemic Lupus Erythematosus [J].

Kamen, Diane L. ;

Strange, Charlie .

CLINICS IN CHEST MEDICINE, 2010, 31 (03) :479-+

[5] Diffuse alveolar hemorrhage in systemic lupus erythematosus: risk factors and clinical outcome: results from affiliated hospitals of Catholic University of Korea [J].

Kwok, S-K ;

Moon, S-J ;

Ju, J. H. ;

Park, K-S ;

Kim, W-U ;

Cho, C-S ;

Kim, H-Y ;

Park, S-H .

LUPUS, 2011, 20 (01) :102-107

[6] Successful treatment of refractory immune thrombocytopenia with anti-CD20 antibody in a patient with systemic lupus erythematosus [J].

Lee, J-W ;

Kim, H-A ;

Sung, J-M ;

Suh, C-H .

LUPUS, 2010, 19 (02) :227-228

[7] Respiratory manifestations of systemic lupus erythematosus: old and new concepts [J].

Maria Pego-Reigosa, Jose ;

Medeiros, Dina A. ;

Isenberg, David A. .

BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY, 2009, 23 (04) :469-480

[8] Recurrent diffuse alveolar haemorrhage in a patient with systemic lupus erythematosus: long-term benefit of rituximab [J].

Martinez-Martinez, M. U. ;

Abud-Mendoza, C. .

LUPUS, 2012, 21 (10) :1124-1127

[9] Focus on research: The B cell - Old player, new position on the team [J].

McFarland, Henry F. .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (07) :664-665

[10] Rituximab as early therapy for pulmonary haemorrhage in systemic lupus erythematosus [J].

Narshi, Chetan B. ;

Haider, Seema ;

Ford, Charlotte M. ;

Isenberg, David A. ;

Giles, Ian P. .

RHEUMATOLOGY, 2010, 49 (02) :392-394