High-water-absorbing calcium alginate fibrous scaffold fabricated by microfluidic spinning for use in chronic wound dressings

被引：43

作者：

Cai, Jie ^{[1
]}

Chen, Xiaojing ^{[2
,3
]}

Wang, Xiaojing ^{[4
]}

Tan, Yulu ^{[1
]}

Ye, Dongdong ^{[1
]}

Jia, Yongtang ^{[1
]}

Liu, Peifeng ^{[2
,3
]}

Yu, Hui ^{[1
]}

机构：

[1] Wuyi Univ, Coll Text Mat & Engn, Engn Technol Res Ctr Funct Text Higher Educ Guang, Jiangmen 529020, Peoples R China

[2] Shanghai Jiao Tong Univ, Shanghai Canc Inst, Renji Hosp, Sch Med,State Key Lab Oncogenes & Related Genes, Shanghai 200032, Peoples R China

[3] Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Cent Lab, Shanghai 200127, Peoples R China

[4] Jiangmen Cent Hosp, Jiangmen 529030, Guangdong, Peoples R China

来源：

RSC ADVANCES | 2018年 / 8卷 / 69期

基金：

中国国家自然科学基金;

关键词：

FIBERS; HYDROGELS; MICROFIBERS; CHITOSAN;

D O I：

10.1039/c8ra06922k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

More and more water-absorbing wound dressings have been studied since moist wound-healing treatment can effectively promote the healing of wounds. In this work, we introduce a novel method to produce improved wound dressings with high-water-absorbance. A high-water-absorbing calcium alginate (Ca-Alg) fibrous scaffold was fabricated simply by microfluidic spinning and centrifugal reprocessing. The structure and physical properties of the scaffold were characterized, and its water-absorbing, cytotoxicity properties and other applicability to wound dressings were comprehensively evaluated. Our results indicate that this material possesses high water-absorbing properties, is biocompatible, and has a 3D structure that mimics the extracellular matrix, while Ca-Alg fibers loaded with silver nanoparticles (AgNPs) exhibit broad-spectrum antibacterial activities; these properties meet the requirements for promoting the healing of chronic wounds and are widely applicable to wound dressings.

引用

页码：39463 / 39469

页数：7

共 40 条

[1]

[Anonymous], 2015, J. Microb. Biochem. Technol, DOI [10.4172/1948-5948.1000212, DOI 10.4172/1948-5948.1000212]

[2]

BARNETT SE, 1987, ANN ROY COLL SURG, V69, P153

[3] Alginate-hyaluronan composite hydrogels accelerate wound healing process [J].

Catanzano, O. ;

D'Esposito, V. ;

Acierno, S. ;

Ambrosio, M. R. ;

De Caro, C. ;

Avagliano, C. ;

Russo, P. ;

Russo, R. ;

Miro, A. ;

Ungaro, F. ;

Calignano, A. ;

Formisano, P. ;

Quaglia, F. .

CARBOHYDRATE POLYMERS, 2015, 131 :407-414

[4] Electrospinning versus microfluidic spinning of functional fibers for biomedical applications [J].

Cheng, Jie ;

Jun, Yesl ;

Qin, Jianhua ;

Lee, Sang-Hoon .

BIOMATERIALS, 2017, 114 :121-143

[5] Development of two alginate-based wound dressings [J].

Chiu, Chih-Tung ;

Lee, Jui-Sheng ;

Chu, Chi-Shung ;

Chang, Yi-Pin ;

Wang, Yng-Jiin .

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2008, 19 (06) :2503-2513

[6] Microfluidic fabrication of microengineered hydrogels and their application in tissue engineering [J].

Chung, Bong Geun ;

Lee, Kwang-Ho ;

Khademhosseini, Ali ;

Lee, Sang-Hoon .

LAB ON A CHIP, 2012, 12 (01) :45-59

[7] Microfluidic fabrication of chitosan microfibers with controllable internals from tubular to peapod-like structures [J].

He, Xiao-Heng ;

Wang, Wei ;

Deng, Ke ;

Xie, Rui ;

Ju, Xiao-Jie ;

Liu, Zhuang ;

Chu, Liang-Yin .

RSC ADVANCES, 2015, 5 (02) :928-936

[8]

Hoefer D., 2015, J MATER SCI-MATER M, V26, P1

[9] Microfluidic spinning of micro- and nano-scale fibers for tissue engineering [J].

Jun, Yesl ;

Kang, Edward ;

Chae, Sukyoung ;

Lee, Sang-Hoon .

LAB ON A CHIP, 2014, 14 (13) :2145-2160

[10] Microfluidic Spinning of Flat Alginate Fibers with Grooves for Cell-Aligning Scaffolds [J].

Kang, Edward ;

Choi, Yoon Young ;

Chae, Su-Kyoung ;

Moon, Jin-Hee ;

Chang, Joon-Young ;

Lee, Sang-Hoon .

ADVANCED MATERIALS, 2012, 24 (31) :4271-+

← 1 2 3 4 →