52 Years of Lassa Fever Outbreaks in Nigeria, 1969-2020: An Epidemiologic Analysis of the Temporal and Spatial Trends

被引：15

作者：

Agbonlahor, Dennis E. ^{[1
,2
]}

Akpede, George O. ^{[3
,4
]}

Happi, Christian T. ^{[5
,6
]}

Tomori, Oyewale ^{[7
,8
]}

机构：

[1] Edo State Univ, Coll Med Sci, Dept Med Lab Sci, Uzairue, Edo, Nigeria

[2] Lahor Res Labs & Med Ctr, Benin, Edo, Nigeria

[3] Ambrose Alli Univ, Coll Med, Dept Paediat, PMB 14, Ekpoma, Edo, Nigeria

[4] Irrua Specialist Teaching Hosp, Inst Lassa Fever Res & Control, Irrua, Edo, Nigeria

[5] Redeemers Univ, Dept Biol Sci, Ede, Ogun, Nigeria

[6] Redeemers Univ, African Ctr Excellence Genom Infect Dis, Ede, Ogun State, Nigeria

[7] Redeemers Univ, Ede, Osun, Nigeria

[8] Fed Minist Hlth, Natl LabTech Working Grp, Abuja, Nigeria

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2021年 / 105卷 / 04期

关键词：

VIRUS-DISEASE; WEST-AFRICA; CLINICAL-FEATURES; MASTOMYS-NATALENSIS; SIERRA-LEONE; EDO STATE; DIAGNOSIS; INFECTION; CARE; SURVEILLANCE;

D O I：

10.4269/ajtmh.20-1160

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The year 2020 made 52 years since the first report of Lassa fever (LF) outbreaks from Nigeria, but what progress has been made in its control? We sought to answer this through an epidemiologic analysis of the temporal and spatial trends of the outbreaks from 1969 to 2020. The analysis showed an overall strengthening of the outbreaks, hallmarked by the change from irregular to regular annual and from limited local to nationwide outbreaks, while there was a sharp contrast between the upward trend in case numbers and downward trend in case fatality. Pending the availability of effective vaccines, greater effort is required to reverse the upward trend in case numbers and sustain the downward trend in case fatality. We discuss the factors associated with the observed trends as well as the prerequisites for further improvements.

引用

页码：974 / 985

页数：12

共 99 条

[1]

Agbonlahor DE, 2017, J VECTOR DIS, V54, P146

[2]

Agbonlahor DE, 1991, J MED LAB SCI, V1, P1

[3]

Agbonlahor DE, 1998, AMBROSE ALLI INAUGUR, V9

[4] Containing a Lassa fever epidemic in a resource-limited setting: outbreak description and lessons learned from Abakaliki, Nigeria (January-March 2012) [J].

Ajayi, Nnennaya A. ;

Nwigwe, Chinedu G. ;

Azuogu, Ben N. ;

Onyire, Benson N. ;

Nwonwu, Elizabeth U. ;

Ogbonnaya, Lawrence U. ;

Onwe, Francis I. ;

Ekaete, Tobin ;

Guenther, Stephan ;

Ukwaja, Kingsley N. .

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2013, 17 (11) :E1011-E1016

[5] Real-time Metagenomic Analysis of Undiagnosed Fever Cases Unveils a Yellow Fever Outbreak in Edo State, Nigeria [J].

Ajogbasile, Fehintola, V ;

Oguzie, Judith U. ;

Oluniyi, Paul E. ;

Eromon, Philomena E. ;

Uwanibe, Jessica N. ;

Mehta, Samar B. ;

Siddle, Katherine J. ;

Odia, Ikponmwosa ;

Winnicki, Sarah M. ;

Akpede, Nosa ;

Akpede, George ;

Okogbenin, Sylvanus ;

Ogbaini-Emovon, Ephraim ;

MacInnis, Bronwyn L. ;

Folarin, Onikepe A. ;

Modjarrad, Kayvon ;

Schaffner, Stephen F. ;

Tomori, Oyewale ;

Ihekweazu, Chikwe ;

Sabeti, Pardis C. ;

Happi, Christian T. .

SCIENTIFIC REPORTS, 2020, 10 (01) :3180

[6] Quantifying the seasonal drivers of transmission for Lassa fever in Nigeria [J].

Akhmetzhanov, Andrei R. ;

Asai, Yusuke ;

Nishiura, Hiroshi .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2019, 374 (1775)

[7] Prevalence of Lassa Virus Disease (LVD) in Nigerian children with fever or fever and convulsions in an endemic area [J].

Akhuemokhan, Odigie C. ;

Ewah-Odiase, Rosemary O. ;

Akpede, Nosa ;

Ehimuan, Jacqueline ;

Adomeh, Donatus I. ;

Odia, Ikpomwonsa ;

Olomu, Sylvia C. ;

Pahlmann, Meike ;

Becker-Ziaja, Beate ;

Happi, Christian T. ;

Asogun, Danny A. ;

Okogbenin, Sylvanus A. ;

Okokhere, Peter O. ;

Dawodu, Osagie S. ;

Omoike, Irekpono U. ;

Sabeti, Pardis C. ;

Guenther, Stephan ;

Akpede, George O. .

PLOS NEGLECTED TROPICAL DISEASES, 2017, 11 (07)

[8] Spatial and temporal trends of the Lassa fever epidemic in Nigeria 2001-2009, with particular reference to the Edo State experience [J].

Akpede, G. ;

Asogun, D. ;

Okokhere, P. ;

Okogbenin, S. ;

Akpan, H. ;

Ehiemuan, J. ;

Happi, C. ;

Gunther, S. .

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2010, 14 :E476-E477

[9] Caseload and Case Fatality of Lassa Fever in Nigeria, 2001-2018: A Specialist Center's Experience and Its Implications [J].

Akpede, George O. ;

Asogun, Danny A. ;

Okogbenin, Sylvanus A. ;

Dawodu, Simeon O. ;

Momoh, Mojeed O. ;

Dongo, Andrew E. ;

Ike, Chiedozie ;

Tobin, Ekaete ;

Akpede, Nosa ;

Ogbaini-Emovon, Ephraim ;

Adewale, Adetunji E. ;

Ochei, Oboratare ;

Onyeke, Frank ;

Okonofua, Martha O. ;

Atafo, Rebecca O. ;

Odia, Ikponmwosa ;

Adomeh, Donatus I. ;

Odigie, George ;

Ogbeifun, Caroline ;

Muebonam, Ekene ;

Ihekweazu, Chikwe ;

Ramharter, Michael ;

Colubri, Andres ;

Sarbeti, Pardis C. ;

Happi, Christian T. ;

Gunther, Stephan ;

Agbonlahor, Dennis E. .

FRONTIERS IN PUBLIC HEALTH, 2019, 7

[10] Acute Abdomen in Pediatric Patients With Lassa Fever: Prevalence and Response to Nonoperative Management [J].

Akpede, George O. ;

Adetunji, Adewale E. ;

Udefiagbon, Ernest O. ;

Eluehike, Sylvester O. ;

Odike, Angela I. ;

Ewah-Odiase, Rosemary O. ;

Omosofe, Folorunso O. ;

Akerele, Johnbull M. ;

Atafo, Rebecca O. ;

Okonofua, Martha O. ;

Onyeke, Imonifome ;

Oyedeji, Omobolaji A. ;

Mbanefo, Kaine ;

Ogbaini-Emovon, Ephraim ;

Okokhere, Peter O. ;

Guenther, Stephan ;

Dongo, Andrew E. .

JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY, 2019, 8 (06) :519-524

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