Treatment of thrombotic thrombocytopenic purpura

被引：1
|
作者：
Galstyan, Gennadii M. [1 ]
Maschan, Alexei A. [2 ]
Klebanova, Elizaveta E. [1 ]
Kalinina, Irina I. [2 ]
机构：
[1] Natl Res Ctr Hematol, Moscow, Russia
[2] Rogachev Natl Med Res Ctr Pediat Hematol Oncol &, Moscow, Russia
来源：
TERAPEVTICHESKII ARKHIV | 2021年 / 93卷 / 06期
关键词：
ADAMTS13; thrombotic thrombocytopenic purpura; pregnancy; therapeutic plasma exchange; rituximab; cyclosporine A; bortezomib; N-acetylcysteine; caplacizumab; recombinant ADAMTS13; VON-WILLEBRAND-FACTOR; THERAPEUTIC PLASMA-EXCHANGE; CRYOPRECIPITATE-POOR PLASMA; LONG-TERM OUTCOMES; ADAMTS13; ACTIVITY; N-ACETYLCYSTEINE; RECOMBINANT ADAMTS13; PREGNANCY OUTCOMES; RITUXIMAB THERAPY; REPLACEMENT FLUID;
D O I：
10.26442/00403660.2021.06.200894
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The review discusses approaches to treatment of acquired thrombotic thrombocytopenic purpura (aTTP). In patients with aTTP plasma exchanges, glucocorticosteroids allow to stop an acute attack of TTP, and use of rituximab allows to achieve remission. In recent years, caplacizumab has been used. Treatment options such as cyclosporin A, bortezomib, splenectomy, N-acetylcysteine, recombinant ADAMTS13 are also described. Separately discussed issues of management of patients with TTP during pregnancy, and pediatric patients with TTP.
引用
收藏
页码：736 / 745
页数：10
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