Clinical Usefulness of Bronchoalveolar Lavage Cellular Analysis and Lymphocyte Subsets in Diffuse Interstitial Lung Diseases

被引:28
作者
Lee, Wookeun [1 ]
Chung, Wha Soon [1 ]
Hong, Ki-Sook [1 ]
Huh, Jungwon [1 ]
机构
[1] Ewha Womans Univ, Sch Med, Dept Lab Med, Seoul 158710, South Korea
关键词
Bronchoalveolar lavage; Lymphocyte subsets; Sarcoidosis; Pulmonary eosinophilia; Interstitial lung diseases; CD4/CD8; RATIO; BAL FLUID; SARCOIDOSIS; GUIDELINES; DIAGNOSIS; UTILITY;
D O I
10.3343/alm.2015.35.2.220
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Background: Diffuse interstitial lung diseases (DILDs) form a part of a heterogeneous group of respiratory diseases. Bronchoalveolar lavage (BAL) analysis has been used for differential diagnosis of DILDs, but their clinical usefulness is controversial. The aim of this study was to investigate the clinical usefulness of BAL cellular analysis with lymphocyte subsets for the differential diagnosis of DILDs. Methods: A total of 69 patients diagnosed with DILDs were enrolled. Basic demographic data, BAL cellular analysis with lymphocyte subsets, histology, and high resolution computed tomogram (HRCT) findings were analyzed and compared as per disease subgroup. Results: Significant differences were found between groups in the proportion of neutrophils (P=0.0178), eosinophils (P=0.0003), T cells (P=0.0305), CD4 cells (P=0.0002), CD8 cells (P<0.0001), and CD4/CD8 ratio (P<0.0001). These findings were characteristic features of eosinophilic pneumonia and sarcoidosis. Other parameters were not significantly different between groups. At the cut-off value of 2.16 for sarcoidosis, CD4/CD8 ratio showed sensitivity of 91.7% (95% CI, 61.5-98.6%) and specificity of 84.2% (95% CI, 72.1-92.5%). Conclusions: Routine analysis of BAL lymphocyte subset may not provide any additional benefit for differential diagnosis of DILDs, except for conditions where BAL is specifically indicated, such as eosinophilic pneumonia or sarcoidosis.
引用
收藏
页码:220 / 225
页数:6
相关论文
共 20 条
[1]  
[Anonymous], 1990, Am Rev Respir Dis, V141, pS169
[2]  
COSTABEL U, 1990, EUR RESPIR J, V3, P946
[3]  
Costabel U, 1990, EUR RESPIR J, V3, P961
[4]   Diagnostic role of BAL fluid CD4/CD8 ratio in different radiographic and clinical forms of pulmonary sarcoidosis [J].
Danila, Edvardas ;
Norkuniene, Jolita ;
Jurgauskiene, Laimute ;
Malickaite, Radvile .
CLINICAL RESPIRATORY JOURNAL, 2009, 3 (04) :214-221
[5]   Report of ERS Task Force: guidelines for measurement of acellular components and standardization of BAL [J].
Haslam, PL ;
Baughman, RP .
EUROPEAN RESPIRATORY JOURNAL, 1999, 14 (02) :245-248
[6]   Value of s-ACE, BAL lymphocytosis, and CD4+/CD8+and CD103+CD4+/CD4+T-cell ratios in diagnosis of sarcoidosis [J].
Hyldgaard, C. ;
Kaae, S. ;
Riddervold, M. ;
Hoffmann, H. J. ;
Hilberg, O. .
EUROPEAN RESPIRATORY JOURNAL, 2012, 39 (04) :1037-1039
[7]   Bronchoalveolar Lavage Findings in Patients With Diffuse Interstitial Lung Disease: Prospective Study of a Cohort of 562 Patients [J].
Jara-Palomares, Luis ;
Martin-Juan, Jose ;
Gomez-Izquierdo, Lourdes ;
Cayuela-Dominguez, Aurelio ;
Rodriguez-Becerra, Eulogio ;
Rodriguez-Panadero, Francisco .
ARCHIVOS DE BRONCONEUMOLOGIA, 2009, 45 (03) :111-117
[8]   The CD4/CD8 ratio in BAL fluid is highly variable in sarcoidosis [J].
Kantrow, SP ;
Meyer, KC ;
Kidd, P ;
Raghu, G .
EUROPEAN RESPIRATORY JOURNAL, 1997, 10 (12) :2716-2721
[9]   Diagnostic Approaches to Diffuse Interstitial Lung Diseases [J].
Kim, Dong Soon .
JOURNAL OF THE KOREAN MEDICAL ASSOCIATION, 2009, 52 (01) :5-13
[10]  
KLECH H, 1989, EUR RESPIR J, V2, P561