A concise synthesis of β-sitosterol and other phytosterols

被引：25

作者：

Hang, Jiliang ^{[1
]}

Dussault, Patrick ^{[1
]}

机构：

[1] Univ Nebraska Lincoln, Dept Chem, Lincoln, NE 68588 USA

来源：

STEROIDS | 2010年 / 75卷 / 12期

关键词：

Sitosterol; Campesterol; Phytosterol; Synthesis; Epoxide; Deoxygenation; PLANT STEROLS; PURIFICATION; CRINOSTEROL; ESTERS; OXIDE;

D O I：

10.1016/j.steroids.2010.05.016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A convenient synthesis of sidechain-modified phytosterols is achieved via a temporary masking of the stigmasterol 5,6-alkene as an epoxide. Following performance of the desired modification, the alkene is regenerated through a mild deoxygenation. The approach is applied to the syntheses of beta-sitosterol and campesterol acetate, and suggests a facile route to the (Z)-isomers of Delta(22-23) phytosterols. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：879 / 883

页数：5

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