Functionalized styrene synthesis via palladium-catalyzed C-C cleavage of aryl ketones

被引：5

作者：

Zhang, Xu ^{[1
]}

Wang, Zhen-Yu ^{[1
]}

Wang, Xing ^{[2
]}

Xu, Hui ^{[2
]}

Dai, Hui-Xiong ^{[1
,2
,3
]}

机构：

[1] Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Jiangsu, Peoples R China

[2] Univ Chinese Acad Sci, Chinese Acad Sci Key Lab Receptor Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China

[3] Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Peoples R China

来源：

TETRAHEDRON LETTERS | 2022年 / 95卷

关键词：

Styrene; Ligand-promoted; C-C cleavage; Orthogonal Suzuki-Miyaura coupling; CROSS-COUPLING REACTIONS; SINGLE BOND-CLEAVAGE; HECK REACTION; DIRECTED CLEAVAGE; VINYLATION; ALKENES; DIFUNCTIONALIZATION; PROTOCOL; HALIDES; DESIGN;

D O I：

10.1016/j.tetlet.2022.153721

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report herein the synthesis of functionalized styrenes via palladium-catalyzed Suzuki-Miyaura cross-coupling reaction between aryl ketone derivatives and potassium vinyltrifluoroborate. The employment of pyridine-oxazoline ligand was the key to the cleavage of unstrained C-C bond. A variety of functional groups and biologically important moleculars were well tolerated. The orthogonal Suzuki-Miyaura cou-pling demonstrated the synthetic practicability.(c) 2022 Elsevier Ltd. All rights reserved.

引用

页数：4

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