Proton pump inhibitors: are they overutilised in clinical practice and do they pose significant risk?

被引：30

作者：

Heidelbaugh, J. J. ^{[1
]}

Metz, D. C. ^{[2
]}

Yang, Y. -X. ^{[3
]}

机构：

[1] Univ Michigan, Dept Family Med, Ann Arbor, MI 48109 USA

[2] Univ Penn, Hosp Univ Penn, Perelman Sch Med,Digest & Liver Ctr, Div Gastroenterol,GI Physiol Lab,Acid Pept Disord, Philadelphia, PA 19104 USA

[3] Univ Penn, Perelman Sch Med, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA

来源：

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE | 2012年 / 66卷 / 06期

关键词：

GASTROESOPHAGEAL-REFLUX DISEASE; COMMUNITY-ACQUIRED PNEUMONIA; DIFFICILE-ASSOCIATED DIARRHEA; ZOLLINGER-ELLISON SYNDROME; STRESS-ULCER PROPHYLAXIS; ACID SUPPRESSION; HOSPITALIZED-PATIENTS; OMEPRAZOLE TREATMENT; COLORECTAL-CANCER; HIP FRACTURE;

D O I：

10.1111/j.1742-1241.2012.02921.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Proton pump inhibitors are highly effective acid suppressants with decades of use highlighting positive outcomes in millions of patients worldwide, and they offer minimal risk of adverse events. PPIs are considered overutilised when prescribed without an appropriate indication, when patients are left on them indefinitely without appropriate indications and when they are continued after being utilised for most cases of hospital SUP. While several adverse outcomes have been linked to PPI therapy, most data are from retrospective observational studies that may be subject to confounding and bias.

引用

页码：582 / 591

页数：10

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