Photoactivation and inactivation of Arabidopsis cryptochrome 2

被引：172

作者：

Wang, Qin ^{[1
,2
]}

Zuo, Zecheng ^{[1
,3
]}

Wang, Xu ^{[1
,2
]}

Gu, Lianfeng ^{[1
]}

Yoshizumi, Takeshi ^{[4
]}

Yang, Zhaohe ^{[1
]}

Yang, Liang ^{[1
,3
]}

Liu, Qing ^{[1
,2
,3
]}

Liu, Wei ^{[3
]}

Han, Yun-Jeong ^{[5
,6
]}

Kim, Jeong-Il ^{[5
,6
]}

Liu, Bin ^{[7
]}

Wohlschlegel, James A. ^{[8
]}

Matsui, Minami ^{[4
]}

Oka, Yoshito ^{[1
,4
]}

Lin, Chentao ^{[1
,2
]}

机构：

[1] Fujian Agr & Forestry Univ, Basic Forestry & Prote Res Ctr, Fuzhou 350002, Peoples R China

[2] Univ Calif Los Angeles, Dept Mol Cell & Dev Biol, Los Angeles, CA 90095 USA

[3] Jilin Univ, Coll Plant Sci, Changchun 130062, Peoples R China

[4] RIKEN, Biomass Engn Res Div, Yokohama, Kanagawa 2300045, Japan

[5] Chonnam Natl Univ, Dept Biotechnol, Gwangju 61186, South Korea

[6] Chonnam Natl Univ, Kumho Life Sci Lab, Gwangju 61186, South Korea

[7] Chinese Acad Agr Sci, Inst Crop Sci, Beijing 10081, Peoples R China

[8] Univ Calif Los Angeles, Dept Biol Chem, Los Angeles, CA 90095 USA

来源：

SCIENCE | 2016年 / 354卷 / 6310期

基金：

中国国家自然科学基金;

关键词：

LIGHT-DEPENDENT PHOSPHORYLATION; BLUE-LIGHT; PHYTOCHROME B; UV-B; PROTEIN; CRY2; PHOTORECEPTOR; ACTIVATION; INDUCTION; CELLS;

D O I：

10.1126/science.aaf9030

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cryptochromes are blue-light receptors that regulate development and the circadian clock in plants and animals. We found that Arabidopsis cryptochrome 2 (CRY2) undergoes blue light-dependent homodimerization to become physiologically active. We identified BIC1 (blue-light inhibitor of cryptochromes 1) as an inhibitor of plant cryptochromes that binds to CRY2 to suppress the blue light-dependent dimerization, photobody formation, phosphorylation, degradation, and physiological activities of CRY2. We hypothesize that regulated dimerization governs homeostasis of the active cryptochromes in plants and other evolutionary lineages.

引用

页码：343 / 347

页数：6

共 29 条

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