A systems biology approach to nutritional immunology - Focus on innate immunity

被引：26

作者：

Afacan, Nicole J. ^{[1
]}

Fjell, Christopher D. ^{[1
]}

Hancock, Robert E. W. ^{[1
]}

机构：

[1] Univ British Columbia, Ctr Microbial Dis & Immun Res, Vancouver, BC V5Z 1M9, Canada

来源：

MOLECULAR ASPECTS OF MEDICINE | 2012年 / 33卷 / 01期

基金：

美国国家卫生研究院; 加拿大自然科学与工程研究理事会; 比尔及梅琳达.盖茨基金会; 加拿大健康研究院;

关键词：

Systems biology; Innate immunity; Nutrition; Transcriptomics; Proteomics; Metabolomics; VITAMIN-D-RECEPTOR; TUMOR-NECROSIS-FACTOR; NF-KAPPA-B; POLYUNSATURATED FATTY-ACIDS; TOTAL PARENTERAL-NUTRITION; GENE-EXPRESSION PROFILES; FISH-OIL SUPPLEMENTATION; BLOOD MONONUCLEAR-CELLS; MYCOBACTERIUM-TUBERCULOSIS; METABOLIC SYNDROME;

D O I：

10.1016/j.mam.2011.10.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Innate immunity and nutrient metabolism are complex biological systems that must work in concert to sustain and preserve life. The effector cells of the innate immune system rely on essential nutrients to generate energy, produce metabolic precursors for macromolecule biosynthesis and tune their responses to infectious agents. Thus disruptions to nutritional status have a substantial impact on immune competence and can result in increased susceptibility to infection in the case of nutrient deficiency, or chronic inflammation in the case of over-nutrition. The traditional, reductionist methods used in the study of nutritional immunology are incapable of exploring the extremely complex interactions between nutrient metabolism and innate immunity. Here, we review a relatively new analytical approach, systems biology, and highlight how it can be applied to nutritional immunology to provide a comprehensive view of the mechanisms behind nutritional regulation of the innate immune system. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：14 / 25

页数：12

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