A20 inactivation in ocular adnexal MALT lymphoma

被引：40

作者：

Bi, Yingwen ^{[1
,2
]}

Zeng, Naiyan ^{[1
]}

Chanudet, Estelle ^{[1
]}

Huang, Yuanxue ^{[1
]}

Hamoudi, Rifat A. ^{[1
]}

Liu, Hongxiang ^{[3
,4
]}

Dong, Gehong ^{[1
]}

Watkins, A. James ^{[1
]}

Ley, Steven C. ^{[5
]}

Zou, Lifen ^{[6
]}

Chen, Rongjia ^{[2
]}

Zhu, Xiongzeng ^{[7
]}

Du, Ming-Qing ^{[1
,3
,4
]}

机构：

[1] Univ Cambridge, Div Mol Histopathol, Dept Pathol, Cambridge CB2 2QQ, England

[2] Fudan Univ, Dept Pathol, Eye & ENT Hosp, Shanghai 200433, Peoples R China

[3] Cambridge Univ Hosp NHS Fdn Trust, Addenbrookes Hosp, Dept Histopathol, Cambridge, England

[4] Cambridge Univ Hosp NHS Fdn Trust, Addenbrookes Hosp, Mol Malignancy Lab, Cambridge, England

[5] Natl Inst Med Res, Div Immune Cell Biol, London NW7 1AA, England

[6] Fudan Univ, Eye & ENT Hosp, Dept Radiol, Shanghai 200433, Peoples R China

[7] Fudan Univ, Canc Hosp, Dept Pathol, Shanghai 200433, Peoples R China

来源：

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL | 2012年 / 97卷 / 06期

关键词：

A20; ABIN; ocular adnexal MALT lymphoma; NF-KAPPA-B; SYSTEMIC-LUPUS-ERYTHEMATOSUS; CELL LYMPHOMA; TNFAIP3; A20; SUSCEPTIBILITY; ASSOCIATION; ACTIVATION; MUTATIONS; ABIN-2; GENES;

D O I：

10.3324/haematol.2010.036798

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recent studies showed A20 inactivation by deletion, mutation and promoter methylation in ocular adnexal mucosa-associated lymphoid tissue lymphoma. However, the incidences of A20 abnormalities and their clinical impact remain for the most part unknown. It is also unknown whether ABIN-1 and ABIN-2, the components of the A20 NF-kappa B inhibitor complex, are inactivated by genetic changes in ocular adnexal mucosa-associated lymphoid tissue lymphoma. A total of 105 cases were investigated for A20 mutation/deletion, ABIN-1/2 mutation, MALT1 and IGH involved translocation. Somatic mutation was seen frequently in A20 (28.6%) but rarely in ABIN-1 (1%) and ABIN-2 (1%). A20 mutations were significantly associated with A20 heterozygous deletion, and both were mutually exclusive from the MALT1 or IGH involved translocations. A20 mutation/deletion was also significantly associated with increased expression of the NF-kappa B target genes CCR2, TLR6 and BCL2. The cases with A20 mutation/deletion required significantly higher radiation dosages to achieve complete remission than those without these abnormalities.

引用

页码：926 / 930

页数：5

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